DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and Pax3

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001152992.1	Gene:	Pax3 / 18505	MGIID:	97487	Length:	484	Species:	Mus musculus

Alignment Length:	362	Identity:	77/362 - (21%)
Similarity:	124/362 - (34%)	Gaps:	101/362 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LEKRIEE--------------------------AVPAGQQLQEL-------GMRLRCDDMGSEND 297
            :||:|||                          .||:...:..:       |.....|....|.:
Mouse   114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAE 178

  Fly   298 DMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQP 362
            :..::.:..:|....|..|....|:..|.||:.||            |..:|
Mouse   179 ESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDL------------PLKRK------------- 218

  Fly   363 GMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKD--- 424
               .:|.||.:|..|:.|||:.|....|.....|.|:|....|:|.::::||.|||.:|:|.
Mouse   219 ---QRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGA 280

  Fly   425 NKLPNTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQ-----QAQQQQQSQQQQTQQTPVMNECI 484
            |:|....::    :.....||.:...||.:.:....|     ||.....|...:.|  |:....:
Mouse   281 NQLMAFNHL----IPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQ--PLPPSTV 339

  Fly   485 RSDSLESIGDVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNNNNNNSNLNNNNN 549
            ...::.|..|.||:.    .:|:.....|||..|....|           ..:|..|..:.|..:
Mouse   340 HQSTIPSNADSSSAY----CLPSTRHGFSSYTDSFVPPS-----------GPSNPMNPTIGNGLS 389

  Fly   550 NNQMGHTNLHGHLQQQQSDLMTNLQLHIKQDYDLTAL 586
            ...||....||.:..|.           :.||.|:.|
Mouse   390 PQVMGLLTNHGGVPHQP-----------QTDYALSPL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	19/51 (37%)
Pax3	NP_001152992.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:278709	7/44 (16%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		17/90 (19%)
		Homeobox	222..275	CDD:278475	19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		8/43 (19%)
		Pax7	347..391	CDD:289156	12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910