DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and Nobox

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_570939.1	Gene:	Nobox / 18291	MGIID:	108011	Length:	527	Species:	Mus musculus

Alignment Length:	377	Identity:	83/377 - (22%)
Similarity:	129/377 - (34%)	Gaps:	116/377 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 GHSPHSQMMDL--PLQCSS----TEPPTNTALGLQELGLK-LEKRIEEAVPAGQ-QLQELGMRLR 288
            |..|.:..::.  |||.|:    .:....::|....||.: |.|..||.:.||. ::.:......
Mouse    17 GDKPRTAALETEGPLQDSALPIQDDQDKQSSLPRASLGKRPLSKTSEELMDAGTCRVHKAPTAAA 81

  Fly   289 CDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDE-DLMAETTDGERIIYPWMKKIHV 352
            |... ||.:..|..:|......| .:.:.......|..:|.| ||..|:.:   :...:.||
Mouse    82 CGPQ-SEEEGCSPPERKAESLKP-SISAVPGQATAGSLNSHEGDLKKESLE---VTCQFRKK--- 138

  Fly   353 AGVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNR 417
                            .||.|...|:.|||:.|..:.|....:|.||:..:.::.::|.:|||||
Mouse   139 ----------------TRTLYRSDQLEELERIFQEDHYPDSDKRHEISQMVGVTPQRIMVWFQNR 187

  Fly   418 RMKWKKDNKL--PNTKN------------------VRKKTVDANGNPTP------VAKKPTKRAA 456
            |.||:|..||  ..|||                  :.....|....|.|      |..:|.....
Mouse   188 RAKWRKVEKLNEKETKNGPAAPSADSSQHRSAPELLDPMPTDLEPGPVPPENILDVFPEPPMLLT 252

  Fly   457 SKKQQQAQQQQQSQQQ-------------------------QTQQT-PVMNECIRSDS------- 488
            |::.....|..:..::                         ||.|. |.|.:...|||
Mouse   253 SEQTLTPFQNNEGAERVAVTPPLLSPPPIRRANLPLPLGPVQTPQVLPPMRDVPGSDSIYKDKAY 317

  Fly   489 ---------------LESIG----DVSSSLGN-----PPYIPAAPETTSSYP 516
                           ||.:|    ..||.||:     .|::|..|...|.:|
Mouse   318 VSWGTSIASPPTYSNLEDLGSQDYQASSQLGSFQLSQAPHLPLFPSLQSQFP 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	20/51 (39%)
Nobox	NP_570939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..126		26/110 (24%)
		COG5576	94..213	CDD:227863	37/141 (26%)
		Homeobox	139..192	CDD:278475	20/52 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..245		9/50 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..306		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910