Protein Alignment Dfd and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_477201.1
• Gene: Dfd / 40832
• FlyBaseID: FBgn0000439
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Alignment Length: 271
• Identity: 66/271 - (24%)
• Similarity: 108/271 - (39%)
• Gaps: 87/271 - (32%)

  Fly   324 GDSDSDEDLMAETTDGERIIYPWMKKIHV-AGVANGSYQPGMEPKRQ-RTAYTRHQILELEKEFH 386
            ||.|..:|..|:    ::.:....|.:.: ....:|:.:|....:|: |..:::.|:.|||:.|.
Mouse    97 GDPDPAKDPRAD----KKELCALQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFK 157

  Fly   387 YNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPNTKNVRKKTVDANGNPTPVAKKP 451
            ..|||:...|.::|..|.|:..|:||||||||.|.|:..        :.:|::..|.|.|    |
Mouse   158 QQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQR--------QDQTLELLGPPPP----P 210

  Fly   452 TKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIGDVSS------------------- 497
            .:|.|                    .||:   :| |....:||.::
Mouse   211 ARRIA--------------------VPVL---VR-DGKPCLGDPAAYAPAYGVGLNAYGYNAYPY 251

  Fly   498 -SLG----NPPY----IPAAPETTSSYPGSQQHLSNNNNN----GSGNNNNNNNNNNSNLNNNNN 549
             |.|    :|.|    .||||      |.:|...::.|:|    |.|:.|...:......|:
Mouse   252 PSYGGAACSPGYSCAAYPAAP------PAAQPPAASANSNFVNFGVGDLNTVQSPGMPQGNS--- 307

  Fly   550 NNQMGHTNLHG 560
                |.:.|||
Mouse   308 ----GVSTLHG 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeodomain	367..423	CDD:459649	24/56 (43%)
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	22/49 (45%)