DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and ARX

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_620689.1	Gene:	ARX / 170302	HGNCID:	18060	Length:	562	Species:	Homo sapiens

Alignment Length:	328	Identity:	78/328 - (23%)
Similarity:	119/328 - (36%)	Gaps:	75/328 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 ASAGGYSSNYANATPPSHPHSHPHAHPHQSLG---------------YYVHHAPEFISAGAVHSD 171
            |:|...:.....|.||..|.:.|...| ...|               ..:..||: :|.....|.
Human   113 AAATATAGPRGEAPPPPPPTARPGERP-DGAGAAAAAAAAAAAAWDTLKISQAPQ-VSISRSKSY 175

  Fly   172 PTNGYGPAANVPNTSN--GGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGSTHSQGHS 234
            ..|| .|....|...:  ||.||.:......|..||.  |.....|||.||.:........:...
Human   176 RENG-APFVPPPPALDELGGPGGVTHPEERLGVAGGP--GSAPAAGGGTGTEDDEEELLEDEEDE 237

  Fly   235 PHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSENDDM 299
            ...:.:   |:....|...:.|..|    ||..:|...|............      :.:|..::
Human   238 DEEEEL---LEDDEEELLEDDARAL----LKEPRRCPVAATGAVAAAAAAA------VATEGGEL 289

  Fly   300 SEEDRLMLDRSPDELGSNDNDDDL---GDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGSYQ 361
            |.::.|:|  .|::....|.:|.:   ..|||:|.|:..
Human   290 SPKEELLL--HPEDAEGKDGEDSVCLSAGSDSEEGLLKR-------------------------- 326

  Fly   362 PGMEPKRQRTAYTRHQILELEKEF---HYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKK 423
               :.:|.||.:|.:|:.|||:.|   ||....||.   |:|..|.|:|.::::||||||.||:|
Human   327 ---KQRRYRTTFTSYQLEELERAFQKTHYPDVFTRE---ELAMRLDLTEARVQVWFQNRRAKWRK 385

  Fly   424 DNK 426
            ..|
Human   386 REK 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	24/54 (44%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..255		30/144 (21%)
		Homeobox	332..385	CDD:395001	25/55 (45%)
		OAR	526..544	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	530..543
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910