DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and Hoxd3

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	336	Identity:	95/336 - (28%)
Similarity:	126/336 - (37%)	Gaps:	102/336 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 THSLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYYVHHAPEFISAGAV 168
            |..||......|....:....|||  .|:.||     .::.::.|||..       |...:|.::
Mouse     9 TLELPECTMQKAAYYENPGLFGGY--GYSKAT-----DTYGYSTPHQPY-------PPPAAANSL 59

  Fly   169 HSD-PTNGYGPAANVPNTSNGGGGGGSGAVLGGGAV-GGSANGYYGGYGGGYGTANGSVGSTHSQ 231
            .|| |::    |.::.:::........||.|.|..: .|:.|    ..|||.|.....:.|....
Mouse    60 DSDYPSS----ACSIQSSAPLRAPAHKGAELNGSCMRPGTGN----SQGGGGGNQPPGLNSEQQP 116

  Fly   232 GHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRCDDMGSEN 296
            ...|......||     ...|||...|               |||
Mouse   117 PQPPPPPPPTLP-----PSSPTNPGSG---------------VPA-------------------- 141

  Fly   297 DDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVAGVANGS-- 359
                                ......|..|.|...:..:       |:||||:.........|
Mouse   142 --------------------KKTKGGLSASSSSSTISKQ-------IFPWMKESRQNSKQKNSCA 179

  Fly   360 ---------YQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQ 415
                     ..||...||.|||||..|::|||||||:||||.|.||:|:|:.|.|:|||||||||
Mouse   180 TSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQ 244

  Fly   416 NRRMKWKKDNK 426
            |||||:|||.|
Mouse   245 NRRMKYKKDQK 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	38/51 (75%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		42/235 (18%)
		Antp-type hexapeptide	161..166		3/4 (75%)
		Homeobox	199..251	CDD:278475	38/51 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280
		DUF4074	370..431	CDD:290032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810