DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and En1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_034263.2	Gene:	En1 / 13798	MGIID:	95389	Length:	401	Species:	Mus musculus

Alignment Length:	438	Identity:	101/438 - (23%)
Similarity:	145/438 - (33%)	Gaps:	141/438 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GAVGGGAGVG-----SVGGGGAGGMTGH--PHSMHPADMVSDY------MAHHHNPHSHSHSHTH 105
            |||...|..|     |.|..|:.|..|.  |.|..||......      :|||  ||
Mouse    17 GAVAAAAPSGLSLSLSPGASGSSGSDGDSVPVSPQPAPPSPPAAPCLPPLAHH--PH-------- 71

  Fly   106 SLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSH---------PHAHPHQSLGYYVHH--A 159
             ||.|..                   ....||..|..|         |.|..|::..:::.:  .
Mouse    72 -LPPHPP-------------------PPPPPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILR 116

  Fly   160 PEFISAGAVHSDPTNGYGPAANVPNTSNGGG---GGGSGAVLGGGAVGGSANGYYGGYGGGYGTA 221
            |:|   |.....|.    |...|.:.:.|||   ||||......|..|...:..:
Mouse   117 PDF---GCKKEQPL----PQLLVASAAAGGGAAAGGGSRVERDRGQTGAGRDPVH---------- 164

  Fly   222 NGSVGSTHSQGHSPHSQMMDLPLQCS---------STEPPTNTALGLQELGLKLEKRIEEAVPAG 277
              |:|:..|...|         |.|:         .::|.|..:.|..:.|.........|..|.
Mouse   165 --SLGTRASGAAS---------LLCAPDANCGPPDGSQPATAVSAGASKAGNPAAAAAAAAAAAA 218

  Fly   278 QQLQEL------------GMRLRCDDMGSENDDMSEEDRLMLDRSPDELGSNDNDDDLGDSDSDE 330
            ..:...            |........|::.....|.:..:|      |..:.|...:..:||.:
Mouse   219 AAVAAAAAAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAIL------LMGSANGGPVVKTDSQQ 277

  Fly   331 DLMAETTDGERIIYPWMKKIHVAGVANGSYQPGMEP--------------KRQRTAYTRHQILEL 381
            .|:            |...::....::   :|...|              ||.|||:|..|:..|
Mouse   278 PLV------------WPAWVYCTRYSD---RPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRL 327

  Fly   382 EKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLPN 429
            :.||..|||:|.:||..:|..|.|:|.||||||||:|.|.||...:.|
Mouse   328 KAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATGIKN 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	28/51 (55%)
En1	NP_034263.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		27/114 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..167		10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..253		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..315		3/21 (14%)
		Homeobox	315..368	CDD:278475	28/52 (54%)
		Engrail_1_C_sig	370..399	CDD:287495	1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910