DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and AgaP_AGAP013157

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_003436884.1	Gene:	AgaP_AGAP013157 / 11175794	VectorBaseID:	AGAP013157	Length:	447	Species:	Anopheles gambiae

Alignment Length:	521	Identity:	128/521 - (24%)
Similarity:	185/521 - (35%)	Gaps:	181/521 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SHSHSHTHSLPHHH-----SNSAISGHHQASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYY-- 155
            |.::.::.:..::|     |||..:.|||.      .||.|      .....:.:|:|:..:|
Mosquito    30 SSAYGYSATAQYNHDEQFSSNSLHTRHHQL------ENYGN------QFDSYYGYPYQTTAHYSL 82

  Fly   156 ---VHHAPEFISAGAVHSDPTNGYGPA----ANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGG 213
               ..|..|:.            |.|.    :||...|
Mosquito    83 CGAQEHLEEYF------------YKPTEVERSNVEKRS--------------------------- 108

  Fly   214 YGGGYGTANGSVGSTHSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQ 278
                                        ....|.:.:||...    :::..|.....|:..||.:
Mosquito   109 ----------------------------CEKSCETIKPPAMK----RKISEKETNDNEKDSPALR 141

  Fly   279 QL-------------------QELGMRLRCDDMGSENDDMS--EEDRLMLD---RSPDELGSNDN 319
            .|                   .|...|:.. .:|..|..:|  ..||::.|   .||::  ::|:
Mosquito   142 ALLTNPAKKLKYNPHYAHSMTNESSRRIEA-TIGYNNGFLSPAASDRIVPDIVPLSPNK--TDDS 203

  Fly   320 DDDLGDSDSDEDLMA-----ETTDGERIIYPWMK----------------KIHVAGVANGSYQPG 363
            .|.|.|:.|.:|::.     .|.:..|.|....|                .|...||.|   .|.
Mosquito   204 IDSLLDNSSKQDIVTMQCVDYTLNSLRQITATPKYDGVSTPPLSPKNMESAISSQGVEN---HPK 265

  Fly   364 MEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRRMKWKKDNKLP 428
            ...||.|.:|:|||.:|||||||:||||.||||||||..|.|:||||||||||||||.||||..
Mosquito   266 ESSKRTRQSYSRHQTIELEKEFHFNRYLNRRRRIEIASMLKLTERQIKIWFQNRRMKAKKDNSA- 329

  Fly   429 NTKNVRKKTVDANGNPTPVAKKPTKRAASKKQQQAQQQQQSQQQQTQQTPVMNECIRSDSLESIG 493
             :.|....|.|        .:.|.:...|....|:|....|..|...    ||        .|..
Mosquito   330 -SANTPDLTYD--------GEIPQQSLESIVAVQSQHHTASDSQPLS----MN--------TSAS 373

  Fly   494 DVSSSLGNPPYIPAAPETTSSYPGSQQHLSNNNNNGSGNNNNNNNNN-------NSNLNNNNNNN 551
            .|:..:|.  :.........|||.|  |.|:|......|.:|.:.:|       :|.|.|.::.:
Mosquito   374 TVTQQVGR--HCDQQMMDGWSYPHS--HYSHNQYYYMQNYSNYSQHNFQTAGPISSGLYNGHHPH 434

  Fly   552 Q 552
            |
Mosquito   435 Q 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	40/51 (78%)
AgaP_AGAP013157	XP_003436884.1	FTZ	46..249	CDD:281812	47/288 (16%)
AgaP_AGAP013157	XP_003436884.1	Homeobox	271..324	CDD:278475	40/52 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D858478at2759
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820