DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dfd and Hoxa1

DIOPT Version :9

Sequence 1:	NP_477201.1	Gene:	Dfd / 40832	FlyBaseID:	FBgn0000439	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_037207.2	Gene:	Hoxa1 / 103690132	RGDID:	11414885	Length:	334	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	106/434 - (24%)
Similarity:	148/434 - (34%)	Gaps:	161/434 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YNGHYSMTASTGHMSGAVGGGAGVGSVGG-----GGAGGMTGHPHSMHPADMVSDYMAHHHNPHS 98
            |:..:.:|.   ..|.||    ...|.||     ||.|.....||             |||:.|.
  Rat    28 YSSDHGITT---FQSCAV----SANSCGGDDRFLGGRGVQITSPH-------------HHHHHHH 72

  Fly    99 HSHSHTHSLPHHHSNSAISGHHQASAGGYSSNYANATPPSHPHSHPHAHPHQSLGYYVHHAPEFI 163
            |....|:..   ..|..:|..|.:....|.:.  |.:.|..|:....
  Rat    73 HPQPATYQT---SGNLGVSYSHSSCGPSYGAQ--NFSAPYGPYGLNQ------------------ 114

  Fly   164 SAGAVHSDPTNGYGPAANVPNTSNGGGGGGSGAVLGGGAVGGSANGYYGGYGGGYGTANGSVGST 228
                 .:|.:.||.|.|....:.|          |....|  ..:.::.||.|      |:|||.
  Rat   115 -----EADVSGGYPPCAPAVYSGN----------LSSPMV--QHHHHHQGYAG------GTVGSP 156

  Fly   229 ----HSQGHSPHSQMMDLPLQCSSTEPPTNTALGLQELGLKLEKRIEEAVPAGQQLQELGMRLRC 289
                ||.|.  ..|.:.|....:|..|              |....:||               |
  Rat   157 QYIHHSYGQ--EHQSLALATYNNSLSP--------------LHASHQEA---------------C 190

  Fly   290 DDMGSENDDMSEE-DRLMLDRSPDELGSNDNDDDLGDSDSDEDLMAETTDGERIIYPWMKKIHVA 353
            ....||....::. |.:.:.|:|.:.|                                 |:
  Rat   191 RSPASETSSPAQTFDWMKVKRNPPKTG---------------------------------KV--- 219

  Fly   354 GVANGSYQPGMEPKRQRTAYTRHQILELEKEFHYNRYLTRRRRIEIAHTLVLSERQIKIWFQNRR 418
                |.|....:|...||.:|..|:.|||||||:|:||||.||:|||.:|.|:|.|:||||||||
  Rat   220 ----GEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRR 280

  Fly   419 MKWKKDNK---LP-----------NTKNVRKKTVDANGNPTPVA 448
            ||.||..|   ||           .|:...:|:..:...|:|.:
  Rat   281 MKQKKREKEGLLPISPATPPGSDEKTEESSEKSSSSPSAPSPAS 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dfd	NP_477201.1	Homeobox	370..422	CDD:278475	35/51 (69%)
Hoxa1	NP_037207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..82		8/36 (22%)
		Interaction with OGT. /evidence=ECO:0000250\|UniProtKB:P09022	74..202		36/204 (18%)
		COG5576	175..>285	CDD:227863	51/178 (29%)
		Antp-type hexapeptide	203..208		1/4 (25%)
		Homeobox	232..284	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..334		12/45 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910