DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ama and Igsf9

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	357	Identity:	87/357 - (24%)
Similarity:	138/357 - (38%)	Gaps:	66/357 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FCLAISLDSVLSAPVISQISKDVVASV----GDSVE-----------FNCTVEEVGQLSV----- 64
            |.|.|.:...|.:|   :|..|.|..|    |.|::           :.|.|..:.|.|.
Mouse    62 FLLPIFIQFGLYSP---RIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFA 123

  Fly    65 --SWA-----KRPSESDTNSVVLSMRNILSL--------PDQRYNVTVTEGPKTGSAIYTFRIQN 114
              ||.     ..|...:|..:||.::.:.::        ..|.|......|...|......::||
Mouse   124 NGSWVHLTVNSPPQFQETPPLVLEVKELEAVTLRCVARGSPQPYVTWKFRGQDLGKGQGQVQVQN 188

  Fly   115 -------IEVSDMGPYECQVLVSATE-KVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHA 171
                   :|....|.|.||  .|::| .:|....|.:..||||.. .|.::.|...|::.|.|.|
Mouse   189 GTLWIRRVERGSAGDYTCQ--ASSSEGSITHATQLLVLGPPVIVV-PPSNSTVNSSQDVSLACRA 250

  Fly   172 NGFP-KPTISWARE-----HNAVMPAGGHLLAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLI 230
            ..:| ..|.||.::     |.:.:.:...:|.:.:|.:::....|.|.|.|:..||...|.....
Mouse   251 EAYPANLTYSWFQDGVNVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFLHPPSASA 315

  Fly   231 RVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPT--VVWHKNGVPLQSSRHHEVANTASSS 293
            .:.|.:..|:.|..|:..........:.|.|:..| |.  |.|.|:|..||..:.     ...|.
Mouse   316 YLTVLYPAQVTVMPPETPLPTGMRGVIRCPVRANP-PLLFVTWTKDGQALQLDKF-----PGWSL 374

  Fly   294 GTTTSVLRIDSVGEED-FGDYYCNATNKLGHA 324
            |...|:  |.::|.|: .|:|.|...|.||.|
Mouse   375 GPEGSL--IIALGNENALGEYSCTPYNSLGTA 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	32/152 (21%)
		Ig	37..127	CDD:299845	26/131 (20%)
		IG_like	154..234	CDD:214653	20/85 (24%)
		IGc2	161..223	CDD:197706	17/67 (25%)
		I-set	254..330	CDD:254352	23/74 (31%)
		IGc2	254..322	CDD:197706	20/70 (29%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	12/50 (24%)
		Ig	136..223	CDD:386229	19/88 (22%)
		Ig_3	227..305	CDD:372822	20/78 (26%)
		Ig	341..404	CDD:386229	22/70 (31%)
		Ig	436..500	CDD:319273
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11062
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900