DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and KIRREL3

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	309	Identity:	69/309 - (22%)
Similarity:	124/309 - (40%)	Gaps:	52/309 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AISLDSVLSAPVISQISKDVVASVGDS-VEFNCTVE-EVGQLSVSWAKRPSESDTNSVVLSMRNI 85
            ::::|  :..|.:..:|.:....:.|: |.|:|:.: ........||||.            :.|
Human   247 SVTID--IQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRG------------QII 297

  Fly    86 LSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIA 150
            .....:.|..||.         ||:..:        |..|:| .:|........::.:...|.:.
Human   298 KEASGEVYRTTVD---------YTYFSE--------PVSCEV-TNALGSTNLSRTVDVYFGPRMT 344

  Fly   151 ENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAEPTLRIRSVHRMDRGGYY 215
             ..|:|.||..|.:...:|...|.|..||.|.:..:.|:     |..|.||.::||.:.|.|.|.
Human   345 -TEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVV-----LSNEKTLTLKSVRQEDAGKYV 403

  Fly   216 C---IAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVV---WHKN 274
            |   :.:.|.|:   |.:.:.|...|.|:..:.:.| :.....:::|.::..|.|..:   |.:|
Human   404 CRAVVPRVGAGE---REVTLTVNGPPIISSTQTQHA-LHGEKGQIKCFIRSTPPPDRIAWSWKEN 464

  Fly   275 GVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYY-CNATNKLG 322
            .:...:|..:.|...::..| ..|.|.|.::...||...| |.|.|..|
Human   465 VLESGTSGRYTVETISTEEG-VISTLTISNIVRADFQTIYNCTAWNSFG 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	20/111 (18%)
		Ig	37..127	CDD:299845	17/91 (19%)
		IG_like	154..234	CDD:214653	25/82 (30%)
		IGc2	161..223	CDD:197706	19/64 (30%)
		I-set	254..330	CDD:254352	18/73 (25%)
		IGc2	254..322	CDD:197706	17/71 (24%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352	0/1 (0%)
		Ig2_KIRREL3-like	171..252	CDD:143236	1/6 (17%)
		Ig_2	260..337	CDD:290606	19/106 (18%)
		I-set	341..422	CDD:254352	26/89 (29%)
		IGc2	355..406	CDD:197706	18/55 (33%)
		Ig5_KIRREL3	424..521	CDD:143306	21/91 (23%)
		IG_like	432..521	CDD:214653	19/83 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810