DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ama and KIRREL2

DIOPT Version :9

Sequence 1:NP_731114.2 Gene:Ama / 40831 FlyBaseID:FBgn0000071 Length:341 Species:Drosophila melanogaster
Sequence 2:NP_954649.3 Gene:KIRREL2 / 84063 HGNCID:18816 Length:708 Species:Homo sapiens


Alignment Length:430 Identity:93/430 - (21%)
Similarity:137/430 - (31%) Gaps:147/430 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 MARLRL--LIGLIFCLAISLDSVLSAPVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPS 71
            |.|:|:  |:.|:||..   .....:|...|..:|:|..:|:.....|.:.....| |.|.|.. 
Human     1 MLRMRVPALLVLLFCFR---GRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGL-VQWTKSG- 60

  Fly    72 ESDTNSVVLSMRNILSLPD-QRYNVTVTEGPKTGSAI---YTFRIQNIEVSDMGPYECQVLVSAT 132
                    |::.....||. .||.:       :|:|.   :...|:.:|:.|...||||...:..
Human    61 --------LALGGQRDLPGWSRYWI-------SGNAANGQHDLHIRPVELEDEASYECQATQAGL 110

  Fly   133 EKVTKKLSLQIKTPPVIAE--NTPKSTLVTEGQNLELTCHANGFPKPT--ISWARE--------- 184
            .  ::...|.:..||...:  ..|..:||. |....|||.:.|..:||  :.|.|:         
Human   111 R--SRPAQLHVLVPPEAPQVLGGPSVSLVA-GVPANLTCRSRGDARPTPELLWFRDGVLLDGATF 172

  Fly   185 HNAVMPAGGHLLAEPTLRIRSVHRMDRGGYYCIA------------------------------- 218
            |..::..|.....|.||.:......|...:.|.|                               
Human   173 HQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHT 237

  Fly   219 -QNGE----------------------GQP--------------------------------DKR 228
             |.||                      |.|                                ..|
Human   238 VQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANR 302

  Fly   229 LIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHEVANTASSS 293
            ...::|.|.|.:..:...::..|...|...|:.:|.|.|.|.|.:.|           ......|
Human   303 STALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRG-----------GAQVLGS 356

  Fly   294 GTTTSVLRIDSVGEEDFGDYYCNATNKL-----GHADARL 328
            |.|   ||:.|||.||.|||.|.|...|     |.|:|||
Human   357 GAT---LRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARL 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AmaNP_731114.2 I-set 33..143 CDD:254352 25/113 (22%)
Ig 37..127 CDD:299845 22/93 (24%)
IG_like 154..234 CDD:214653 26/176 (15%)
IGc2 161..223 CDD:197706 20/126 (16%)
I-set 254..330 CDD:254352 29/80 (36%)
IGc2 254..322 CDD:197706 24/72 (33%)
KIRREL2NP_954649.3 IG_like 30..119 CDD:214653 23/107 (21%)
IGc2 38..106 CDD:197706 20/84 (24%)
I-set 126..224 CDD:254352 20/98 (20%)
Ig2_KIRREL3-like 141..223 CDD:143236 16/81 (20%)
Cell attachment site. /evidence=ECO:0000255 149..151 0/1 (0%)
Ig 231..306 CDD:299845 6/74 (8%)
IG_like 234..308 CDD:214653 6/73 (8%)
Ig 312..395 CDD:299845 31/96 (32%)
I-set 317..395 CDD:254352 30/91 (33%)
Ig 397..501 CDD:299845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 545..601
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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