DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ama and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	87/332 - (26%)
Similarity:	147/332 - (44%)	Gaps:	31/332 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SLDSVLSA-PVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSL 88
            :|::|:|. |..:.:.:::....|.:|:..|:|:.:|...|:|.     ....|.:|::.|.:..
  Fly    43 TLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWM-----HFEQSAILTVHNHVIT 102

  Fly    89 PDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLS---LQIKTPPVIA 150
            .:.|.:||..:..|  ...:...|.|::..|.|.|.||:     ..||.|..   :::..||.|.
  Fly   103 RNPRISVTHDKHDK--HRTWFLHINNVQEEDRGRYMCQI-----NTVTAKTQYGFVKVVVPPNID 160

  Fly   151 EN-TPKSTLVTEGQNLELTCHANGFPKPTISWAREH------NAVMPAGGHLLAEPTLRIRSVHR 208
            :. |....:|.||.|:.|.|.|.|.|:|||.|.|:.      |..:..  |.|...:|.:..:.|
  Fly   161 DALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEV--HDLETDSLELERISR 223

  Fly   209 MDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHK 273
            :..|.|.|||.||......:.|:|.|:|.|.:.:....:...:..:..|||.::..|.....|.:
  Fly   224 LHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTR 288

  Fly   274 NGVPL--QSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQ---- 332
            ....:  :||::.........|...|..|.|.:|...|:|:|.|.|.|..|..|..:.|:.
  Fly   289 ENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPP 353

  Fly   333 TVIPVPS 339
            |..|.|:
  Fly   354 TTQPPPT 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	25/112 (22%)
		Ig	37..127	CDD:299845	20/89 (22%)
		IG_like	154..234	CDD:214653	28/85 (33%)
		IGc2	161..223	CDD:197706	25/67 (37%)
		I-set	254..330	CDD:254352	20/77 (26%)
		IGc2	254..322	CDD:197706	18/69 (26%)
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/107 (22%)
		Ig	69..139	CDD:143165	19/76 (25%)
		IG_like	165..249	CDD:214653	28/85 (33%)
		IGc2	172..237	CDD:197706	24/66 (36%)
		IG_like	267..348	CDD:214653	20/80 (25%)
		Ig	270..339	CDD:299845	18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
	7	6.780