DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and robo4

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	311	Identity:	78/311 - (25%)
Similarity:	126/311 - (40%)	Gaps:	32/311 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LDSVLSAPVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPD 90
            |.|.::.|.|.....|||..||.....:|..|...:.::.|.:.....||:.:....:.|: |||
Zfish    64 LVSEINLPRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIV-LPD 127

  Fly    91 -QRYNVTVTEGPKTGS--AIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAEN 152
             ..:..:|..|.|..|  |:|.               |....|.....::..||.|.........
Zfish   128 GSLFFFSVVPGRKGQSHEAVYA---------------CIAHNSIGNATSRNASLHIAALREDFRV 177

  Fly   153 TPKSTLVTEGQNLELTCHAN-GFPKPTISWAREHNAVMPAGGHLL-AEPTLRIRSVHRMDRGGYY 215
            .|....|..|:...:.|... |.|:|.::|.::...:..:..|.. .:..|.|....:.|.|.|.
Zfish   178 QPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTELKGKLIIAPAQKNDSGVYS 242

  Fly   216 CIAQNGEGQPDKRLIRVEVEFRPQIAVQRPK-IAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQ 279
            |||.|..|..:.|..|:.|..:| :.:::|: ::..:..||:..|...|.|.|::.|.:...||.
Zfish   243 CIASNMIGVRESRAARLSVLAKP-VLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSREQGPLP 306

  Fly   280 SSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHL 330
            :.|:  :.|...|       |:|..|..:|.|.|.|...||||.:.|...|
Zfish   307 NGRY--LINPDHS-------LQIHYVTAQDMGRYSCTVENKLGVSVASAQL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	26/112 (23%)
		Ig	37..127	CDD:299845	21/92 (23%)
		IG_like	154..234	CDD:214653	21/81 (26%)
		IGc2	161..223	CDD:197706	16/63 (25%)
		I-set	254..330	CDD:254352	24/75 (32%)
		IGc2	254..322	CDD:197706	21/67 (31%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	26/114 (23%)
		I-set	71..168	CDD:254352	26/112 (23%)
		I-set	175..261	CDD:254352	21/85 (25%)
		Ig2_Robo	177..261	CDD:143201	21/83 (25%)
		I-set	265..350	CDD:254352	27/94 (29%)
		Ig	282..350	CDD:299845	24/76 (32%)
		FN3	373..448	CDD:214495
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810