DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and KIRREL1

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	339	Identity:	79/339 - (23%)
Similarity:	134/339 - (39%)	Gaps:	65/339 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AISLDSVLSAPVISQISKDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMR---- 83
            :|.|| |...|.::...:......|:.|.|.|                 ::..|..:|..|
Human   214 SIELD-VHHPPTVTLSIEPQTVQEGERVVFTC-----------------QATANPEILGYRWAKG 260

  Fly    84 --NILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQV--LVSATEKVTKKLSLQIK 144
              .|....:.||...|.         |:|..:        |..|:|  .|.:| .|:..:::..
Human   261 GFLIEDAHESRYETNVD---------YSFFTE--------PVSCEVHNKVGST-NVSTLVNVHF- 306

  Fly   145 TPPVIAENTPKSTLVTEGQNLELTCHANGFPKPTISWAREHNAVMP----------AGGHLLAEP 199
            .|.::.:  ||.|....|.::.|||...|.|..|::|.::.:.:.|          ....:|:..
Human   307 APRIVVD--PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNS 369

  Fly   200 T-LRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAELECSVQG 263
            . |.::||.:.|.|.|.|.|........:|.:.:.|...|.|:.:..:.| :.....::||.:..
Human   370 NQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYA-VRGDGGKVECFIGS 433

  Fly   264 YPAPTVV---WHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYY-CNATNKLGHA 324
            .|.|..:   |.:|.:.:.:...:.|..|.|.|| ..|.|.|::|.|.||..:| |.|.|..|..
Human   434 TPPPDRIAWAWKENFLEVGTLERYTVERTNSGSG-VLSTLTINNVMEADFQTHYNCTAWNSFGPG 497

  Fly   325 DARLHLFQ-TVIPV 337
            .|.:.|.: .|:||
Human   498 TAIIQLEEREVLPV 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	20/117 (17%)
		Ig	37..127	CDD:299845	15/95 (16%)
		IG_like	154..234	CDD:214653	22/90 (24%)
		IGc2	161..223	CDD:197706	18/72 (25%)
		I-set	254..330	CDD:254352	24/79 (30%)
		IGc2	254..322	CDD:197706	22/71 (31%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236	3/5 (60%)
		I-set	223..304	CDD:254352	20/115 (17%)
		Ig_2	227..305	CDD:290606	19/112 (17%)
		Ig_2	311..405	CDD:290606	22/95 (23%)
		IG_like	314..405	CDD:214653	22/90 (24%)
		Ig5_KIRREL3	407..504	CDD:143306	27/98 (28%)
		IG_like	416..504	CDD:214653	25/89 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810