DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and NCAM2

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	314	Identity:	80/314 - (25%)
Similarity:	130/314 - (41%)	Gaps:	45/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VISQISKDVVASVGDSVEFNCTVEEVGQ-LSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTV 97
            |...:|| |..|||:|..|.||.  :|: .|:.|.....|.     ::|.:.:         |..
Human    48 VTISLSK-VELSVGESKFFTCTA--IGEPESIDWYNPQGEK-----IISTQRV---------VVQ 95

  Fly    98 TEGPKTGSAIYTFRIQNIEVSDMGPYECQV--LVSATEKVTKKLSLQIKTP--PVIAENTPKSTL 158
            .||.::...||     |..:.|.|.|.||.  ....|::.|..|.:..|..  .|::....|
Human    96 KEGVRSRLTIY-----NANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK--- 152

  Fly   159 VTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGH---LLAEPTLRIRSVHRMDRGGYYCIAQ- 219
              :|::.|:.|..:..|.|.:||...:..|.....:   :||...|:|.::::.|.|.|.|..:
Human   153 --QGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRV 215

  Fly   220 NGEGQPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAEL--ECSVQGYPAPTVVWHKNGVPLQSSR 282
            ...|:.|.|.|.|.|...|.|::.:...........|:  .|...|.|.|.:.|.:||..::.:.
Human   216 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENE 280

  Fly   283 HHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIP 336
            .:.:      .|:.|. |.:.::...|.|.|.|.||||.|..:.:..|...|.|
Human   281 KYIL------KGSNTE-LTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	30/111 (27%)
		Ig	37..127	CDD:299845	25/90 (28%)
		IG_like	154..234	CDD:214653	22/83 (27%)
		IGc2	161..223	CDD:197706	16/65 (25%)
		I-set	254..330	CDD:254352	20/77 (26%)
		IGc2	254..322	CDD:197706	19/69 (28%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	30/110 (27%)
		I-set	47..136	CDD:254352	30/109 (28%)
		I-set	142..218	CDD:254352	18/80 (23%)
		IGc2	153..214	CDD:197706	16/60 (27%)
		Ig	233..326	CDD:299845	23/99 (23%)
		I-set	240..323	CDD:254352	21/89 (24%)
		Ig5_NCAM-2	325..422	CDD:143278	2/3 (67%)
		IG_like	333..420	CDD:214653
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810