DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ama and LRIT3

DIOPT Version :9

Sequence 1:NP_731114.2 Gene:Ama / 40831 FlyBaseID:FBgn0000071 Length:341 Species:Drosophila melanogaster
Sequence 2:NP_940908.3 Gene:LRIT3 / 345193 HGNCID:24783 Length:679 Species:Homo sapiens


Alignment Length:381 Identity:77/381 - (20%)
Similarity:141/381 - (37%) Gaps:100/381 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 YNKRPDMARLRLLIGLIFC---------LAISLDSV---LSAPVISQISKDV------------- 42
            |:.|.|.:..|    |:.|         ..:.:|:|   :...||.:||.:.             
Human    29 YHGRNDGSGSR----LVLCNDMDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVT 89

  Fly    43 ---VASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSV-VLSMRNILSLPDQR----YNVTVTE 99
               |||:..|..:|  ::::.:|.:         |.||: .....::|.:|..|    :|..:|.
Human    90 YNSVASIDPSSFYN--LKQLHELRL---------DGNSLAAFPWASLLDMPLLRTLDLHNNKITS 143

  Fly   100 GPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQN 164
            .|......    ::|:...|:....   |.:......:..:..:.||..:.:.:|...::....|
Human   144 VPNEALRY----LKNLAYLDLSSNR---LTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDN 201

  Fly   165 -LELTCHANGFPKPTISWAREHNAVM-PAGGHLLAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDK 227
             ....||        ||...|.:.|: ||  .:|.:|.:.             |      .:|: 
Human   202 PWFCDCH--------ISKMIELSKVVDPA--IVLLDPLMT-------------C------SEPE- 236

  Fly   228 RLI-----RVEVE--FRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHE 285
            ||.     |.|:|  .:|.:.....||...:..:..|.|...|:|.|.:.|.::.   .|..::.
Human   237 RLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSD---SSPVNYT 298

  Fly   286 VANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLH---LFQTVIPVP 338
            |...:...|...|::.:..:..:|.|||.|.|.|..|.::|.:.   |..|..|:|
Human   299 VIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIP 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AmaNP_731114.2 I-set 33..143 CDD:254352 22/130 (17%)
Ig 37..127 CDD:299845 19/110 (17%)
IG_like 154..234 CDD:214653 17/86 (20%)
IGc2 161..223 CDD:197706 12/63 (19%)
I-set 254..330 CDD:254352 19/78 (24%)
IGc2 254..322 CDD:197706 17/67 (25%)
LRIT3NP_940908.3 LRR 1 56..79 6/22 (27%)
leucine-rich repeat 59..82 CDD:275378 5/22 (23%)
LRR_8 61..117 CDD:290566 12/66 (18%)
LRR 2 80..103 4/22 (18%)
leucine-rich repeat 83..106 CDD:275378 5/24 (21%)
LRR 3 104..128 5/32 (16%)
LRR_8 105..165 CDD:290566 12/75 (16%)
LRR_4 105..146 CDD:289563 9/49 (18%)
leucine-rich repeat 107..130 CDD:275378 5/31 (16%)
LRR 4 129..151 5/21 (24%)
LRR_4 131..170 CDD:289563 7/45 (16%)
leucine-rich repeat 131..154 CDD:275378 4/26 (15%)
LRR 5 152..175 3/25 (12%)
leucine-rich repeat 155..168 CDD:275378 2/15 (13%)
Ig 267..345 CDD:299845 19/80 (24%)
IG_like 267..345 CDD:214653 19/80 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 351..375 2/4 (50%)
FN3 486..550 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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