DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and Dscaml1

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001101611.1	Gene:	Dscaml1 / 315615	RGDID:	1304887	Length:	2111	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	94/347 - (27%)
Similarity:	142/347 - (40%)	Gaps:	60/347 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GLIFCLAISLDSVLSAPVISQIS----------KDVVASVGDSVEFNCTVEEVGQLSVSWAKRPS 71
            |:..|.|  .:||.||...::|:          :::.|..|.....||.|......|:.|.|
  Rat   539 GVYRCTA--RNSVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK--- 598

  Fly    72 ESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVS-DMGPYECQVLVSATEKV 135
                        :.|.|||....|....|        |.::.:::.. |.|.|.|.||:.....:
  Rat   599 ------------DALLLPDNHRQVVFENG--------TLKLTDVQKGMDEGEYLCSVLIQPQLSI 643

  Fly   136 TKKLSLQIKTPPVIA--ENTPKSTLVTEGQNLELTCHANGFPKP-TISWAREHNAVMPAGGHLLA 197
            ::.:.:.:|.||:|.  |..|.|.    ||.|.:.|..:....| .|:|.::...::...|..:.
  Rat   644 SQSVHVAVKVPPLIQPFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIE 704

  Fly   198 E----PTLRIRSVHRMDRGGYYCIAQNGEG--QPDKRLIRVEVEFRPQIAVQRPKIAQMVSHSAE 256
            .    .:|:|.||.....|.|.|||.|...  ..:::||   |...|:..||......:...:..
  Rat   705 SKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLI---VRVPPRFVVQPNNQDGIYGKAGV 766

  Fly   257 LECSVQGYPAPTVVWHK---NGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNAT 318
            |.|||.|||.|.|:|..   :|.|.|   :|.|..|........|.|.|..|.|||.|.|.|.|:
  Rat   767 LNCSVDGYPPPKVMWKHAKGSGNPQQ---YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQAS 828

  Fly   319 NKLGHADARLHLFQTVIPVPSL 340
            |.:| .|....:|.|| .:|::
  Rat   829 NGVG-TDISKAMFLTV-KIPAM 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	22/120 (18%)
		Ig	37..127	CDD:299845	20/100 (20%)
		IG_like	154..234	CDD:214653	22/86 (26%)
		IGc2	161..223	CDD:197706	18/66 (27%)
		I-set	254..330	CDD:254352	30/78 (38%)
		IGc2	254..322	CDD:197706	28/70 (40%)
Dscaml1	NP_001101611.1	IG	101..173	CDD:214652
		IGc2	101..168	CDD:197706
		Ig	183..276	CDD:299845
		IG_like	195..276	CDD:214653
		I-set	291..369	CDD:254352
		IGc2	298..359	CDD:197706
		IGc2	386..447	CDD:197706
		I-set	466..560	CDD:254352	8/22 (36%)
		Ig	466..556	CDD:299845	7/18 (39%)
		IGc2	577..635	CDD:197706	18/80 (23%)
		IG_like	665..744	CDD:214653	21/85 (25%)
		Ig	673..739	CDD:143165	15/65 (23%)
		I-set	748..843	CDD:254352	34/98 (35%)
		Ig7_DSCAM	765..843	CDD:143211	31/81 (38%)
		I-set	849..942	CDD:254352	94/347 (27%)
		Ig	861..949	CDD:299845
		FN3	945..1039	CDD:238020
		FN3	1046..1143	CDD:238020
		fn3	1151..1237	CDD:278470
		FN3	1249..1340	CDD:238020
		IGc2	1364..1428	CDD:197706
		FN3	1442..1532	CDD:238020
		FN3	1546..1618	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900