DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and ncam1a

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	328	Identity:	82/328 - (25%)
Similarity:	144/328 - (43%)	Gaps:	65/328 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGS 105
            :..|.:..:|...|..:...:.:|.||:..:|.::              |::|::.     :.||
Zfish   219 NATADINQAVTLACHADGYPEPTVKWARGNTELES--------------DEKYSLN-----EDGS 264

  Fly   106 AIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIA--ENTPKSTLVTEGQNLELT 168
            .:   .|:::...|.|.|:|.....|.|: :::::|.:...|.|.  ||...|.|   .:.:.||
Zfish   265 EL---TIKDVNKLDEGDYKCIARNKAGER-SEEVTLNVFVQPKITFLENQTASEL---EEQITLT 322

  Fly   169 CHANGFPKPTI---------------SWAR--EHNAVMPAGGHLLAEPTLRIRS-----VHRMDR 211
            |.|.|.|.|.|               ||.|  :|.::   .|:::.....|:.|     |...|.
Zfish   323 CEATGDPTPNIIWSFGRRVFTENEQASWTRPEKHKSL---DGNVVVRSDARVSSLTLKYVQFTDA 384

  Fly   212 GGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPK-IAQMVSHSAELECSVQGYPAPTVVWHKNG 275
            |.|.|.|:|..|| |.:.:.:||.:.|:|  |.|: :.....:.|.:.|....:|..:|:|.::|
Zfish   385 GQYLCTARNSIGQ-DIQSMYLEVRYAPKI--QGPQAVFTWEGNPANITCEALAHPGASVLWFRDG 446

  Fly   276 --VPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIP-V 337
              :|..::.:.::.||     .|.|.|.:....:.|||.|.|.|||.:|.......|.|..:| .
Zfish   447 QQLPSANTTNVKIYNT-----PTVSFLEVTPDSQNDFGSYNCTATNVIGTESKEFILVQADVPSA 506

  Fly   338 PSL 340
            ||:
Zfish   507 PSI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	19/101 (19%)
		Ig	37..127	CDD:299845	16/85 (19%)
		IG_like	154..234	CDD:214653	27/101 (27%)
		IGc2	161..223	CDD:197706	22/83 (27%)
		I-set	254..330	CDD:254352	21/77 (27%)
		IGc2	254..322	CDD:197706	20/69 (29%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845
		I-set	21..111	CDD:254352
		IG_like	121..200	CDD:214653
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	19/104 (18%)
		IG_like	219..298	CDD:214653	19/101 (19%)
		Ig	300..406	CDD:299845	31/112 (28%)
		IG_like	308..406	CDD:214653	29/104 (28%)
		ig	413..498	CDD:278476	23/89 (26%)
		IG_like	415..498	CDD:214653	22/87 (25%)
		fn3	505..589	CDD:278470	2/5 (40%)
		FN3	624..715	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810