DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and Ptprq

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	313	Identity:	58/313 - (18%)
Similarity:	112/313 - (35%)	Gaps:	65/313 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSAPVISQISKDVVASVGDSVEFNC-TVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSL----- 88
            ::|..:|.:.:.:|.....::..:. ||...|..:|...:...:..::..:::.:||.|.
Mouse   525 IAAEHLSYVIRRLVPFTEHTISVSAFTVMGEGPPTVLTVRTREQVPSSIQIINYKNISSSSILLY 589

  Fly    89 --PDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTK-------------- 137
              |.:..|     |..|...||...:.......|...:...|::..:|.|:
Mouse   590 WDPPEYPN-----GKITHYTIYAMELDTNRAFQMTTVDNSFLITGLKKYTRYKMRVAASTHVGES 649

  Fly   138 KLS----LQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKPTISWA--REHNAVMPA----- 191
            .||    |.::||....|::|:...||:....||          :::|:  .:.|.::.|
Mouse   650 SLSEENDLFVRTPEDEPESSPQDVKVTDVSPSEL----------SLTWSPPEKPNGIIIAYEVFY 704

  Fly   192 --GGHLLAEPT---------LRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEV-EFRPQIAVQR 244
              ...|..:.|         |:..:::.:....|   .:.|.|.....|:.|.. |..|..|.:
Mouse   705 QNADALFVKNTSTTNITLSDLKPYTLYNISIQSY---TRLGHGNQSSSLLSVRTSETVPDSAPE- 765

  Fly   245 PKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRHHEVANTASSSGTTT 297
             .|......|.|:|.......:|..:..|..:.|:.|..||.....::|.|.|
Mouse   766 -NITYKNISSEEIEIFFLPPRSPNGIIQKYTIYLKRSNSHEARTIETTSLTLT 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	22/135 (16%)
		Ig	37..127	CDD:299845	15/97 (15%)
		IG_like	154..234	CDD:214653	16/97 (16%)
		IGc2	161..223	CDD:197706	10/79 (13%)
		I-set	254..330	CDD:254352	12/44 (27%)
		IGc2	254..322	CDD:197706	12/44 (27%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020
		fn3	399..>441	CDD:365830
		FN3	570..654	CDD:238020	15/88 (17%)
		fn3	668..744	CDD:365830	13/88 (15%)
		FN3	762..850	CDD:238020	14/58 (24%)
		fn3	857..934	CDD:365830
		FN3	951..1049	CDD:238020
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900