DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and igcm-2

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	79/347 - (22%)
Similarity:	128/347 - (36%)	Gaps:	69/347 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QYNKRPDMARLRLLIGLIFCLAISLDSVLSAPVISQISKDVV--ASVGDSVEFNCTVEEVGQLSV 64
            :::|:|    .|...||...|.:::..|:.:|     ||:.:  ..||..:.|.|..|......:
Worm   102 KFSKQP----TRPEKGLSAKLVVNVPPVIISP-----SKNAIIHKKVGADLIFECKAEGAPSPEI 157

  Fly    65 SWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLV 129
            :|::       |..::|...:|:|                        .|:|..|.|.|.| :.|
Worm   158 TWSR-------NEQIISTSPVLTL------------------------SNLEEGDKGLYTC-LAV 190

  Fly   130 SATEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKP-TISWAREHNAVMPAGG 193
            :.....|..:.::. |...|.:..|.:..|.||.|:...||||..... :.||..|...:.....
Worm   191 NIEGNSTSSIDVRF-TKATILDLIPLNKTVIEGSNVFWHCHANAQATAISYSWLFEKKPIKTTSL 254

  Fly   194 HL---LAEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQ-IAVQRPKIAQMVSHS 254
            .|   :....|.::.|.:.|.|.|.|.|:|..|:.......:.|.:.|: ::..:|........:
Worm   255 GLRSNIRSGDLSLQDVRKSDSGWYTCEAKNSAGETTSSTAYLHVFYPPEPLSSHQPVQTVASGRN 319

  Fly   255 AELECSVQGYPAPT-VVWHKNG--VPLQSSRHHEVANTASSSGTTTSVLRIDSVGEEDFGDYYCN 316
            ..:.|.|...|.|| ..|.|||  :|.|:|.|..::......|                |.|.|.
Worm   320 TTVSCDVIANPTPTSYTWSKNGHYLPTQASSHIIISYAKPGDG----------------GIYGCQ 368

  Fly   317 ATNKLGHAD-ARLHLFQTVIPV 337
            |.|..|... ...||.....||
Worm   369 ADNIAGKGSIVETHLIVAEPPV 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	21/111 (19%)
		Ig	37..127	CDD:299845	18/91 (20%)
		IG_like	154..234	CDD:214653	22/83 (27%)
		IGc2	161..223	CDD:197706	19/65 (29%)
		I-set	254..330	CDD:254352	20/79 (25%)
		IGc2	254..322	CDD:197706	19/70 (27%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653
		Ig	124..200	CDD:386229	22/112 (20%)
		IG_like	214..298	CDD:214653	22/83 (27%)
		Ig_3	309..371	CDD:372822	19/77 (25%)
		Ig	389..467	CDD:386229	2/2 (100%)
		FN3	476..548	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900