DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and Ncam2

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	350	Identity:	88/350 - (25%)
Similarity:	133/350 - (38%)	Gaps:	59/350 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RLRLLI--------GLIFCLAI-SLDSVLSAPVISQI-----SKDVVA----SVGDSVEFNCTVE 57
            |.||.|        |:..|.|. :......|.|:.:|     .::||:    ..|:..|..|.|.
Mouse    75 RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVS 139

  Fly    58 EVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTGSAIYTFRIQNIEVSDMGP 122
            .....:|||.....|            :.::||.|:.|....         ..:|.||..||.|.
Mouse   140 SSPAPAVSWLYHNEE------------VTTIPDNRFAVLANN---------NLQILNINKSDEGI 183

  Fly   123 YECQVLVSATEKVT-KKLSLQIKTPPVIAENTPKSTLVTE-GQNLELTCHANGFPKPTISWAREH 185
            |.|:..|.|..::. :.:.:.:..||.|...........| |:.:.|||.|:|.|.|||||.|..
Mouse   184 YRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKASGSPDPTISWFRNG 248

  Fly   186 NAVMPAGGHLL--AEPTLRIRSVHRMDRGGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRPKIA 248
            ..:.....::|  :...|.:|::...|.|.|.|.|.|..|:..|:...       |:.|| |.|.
Mouse   249 KLIEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFL-------QVFVQ-PHIL 305

  Fly   249 QMVSHSAE------LECSVQGYPAPTVVWHK--NGVPLQSSRHHEVANTASSSGTTTSVLRIDSV 305
            |:.:.:..      |.|..:|.|.|.:.|.:  :||.....................|.|.|..|
Mouse   306 QLKNETTSENGHVTLVCEAEGEPVPEITWKRAIDGVMFSEGDKSPDGRIEVKGQHGRSSLHIRDV 370

  Fly   306 GEEDFGDYYCNATNKLGHADARLHL 330
            ...|.|.|.|.|.:::|.....:||
Mouse   371 KLSDSGRYDCEAASRIGGHQRSMHL 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	26/119 (22%)
		Ig	37..127	CDD:299845	23/98 (23%)
		IG_like	154..234	CDD:214653	25/82 (30%)
		IGc2	161..223	CDD:197706	23/64 (36%)
		I-set	254..330	CDD:254352	18/83 (22%)
		IGc2	254..322	CDD:197706	17/75 (23%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	9/36 (25%)
		I-set	22..111	CDD:254352	9/35 (26%)
		I-set	117..193	CDD:254352	23/96 (24%)
		IGc2	128..189	CDD:197706	20/81 (25%)
		Ig	208..301	CDD:299845	29/99 (29%)
		I-set	215..298	CDD:254352	25/89 (28%)
		Ig	300..397	CDD:299845	24/96 (25%)
		IG_like	308..395	CDD:214653	18/86 (21%)
		IG_like	413..491	CDD:214653
		IGc2	414..482	CDD:197706
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900