DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and Papln

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	366	Identity:	85/366 - (23%)
Similarity:	133/366 - (36%)	Gaps:	122/366 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VVASVGDSVEFNCTVEEVGQLSVSWAK--RPSESDTNSVVLSMRNILSLPDQRYNVTVTEGPKTG 104
            |.|:.|.:|:..|......:....|.|  ||..|:                 ||.:..     .|
Mouse   936 VQAAPGQAVQLFCPGNIPSEFQAGWQKEGRPISSN-----------------RYQLQA-----DG 978

  Fly   105 SAIYTFRIQNIEVSDMGPYEC-------------------------------------------- 125
            |.|    |..:...|.|.|.|
Mouse   979 SLI----ISRLRPEDAGIYSCGSHRPGHEPQEIQLRVTGGDMAVFPEGQPRHFPEPRNPDLGHGP 1039

  Fly   126 ------------QVLVSATEKVTKKLSLQIKTPPVIAENTPKSTLVTEGQNLELTCHANGFPKPT 178
                        :||..:..:...:|.|. :|.|.:.:.:|       ||.:.|||.|.|||.||
Mouse  1040 PHRGTGAEAGGHRVLSPSHPRPATRLRLD-RTQPGVVDASP-------GQRIRLTCRAEGFPVPT 1096

  Fly   179 ISWAREHNAVMPAGGHLLAEPTLRIRS-----VHRMD--RGGYY-CIAQNGEGQPDKRLIRVEVE 235
            |.|.|:        |.|::.|..:::.     :.|:|  .|||| |:|.||:.: |:|.:::.|.
Mouse  1097 IEWQRD--------GQLVSSPRHQVQPDGSLVISRVDVEDGGYYSCVAFNGQDR-DQRWVQLRVL 1152

  Fly   236 FRPQIAVQRPKIAQMVSHSAELECSVQGYPAPTVVWHKNGVPLQSSRH--HEVANTASSSGTTTS 298
            ....|....|.:......:|.|.|.|.| .:..:.|.:||:|:|:..|  |:     |..||
Mouse  1153 RELTITGLPPAVTVAEGDTARLLCVVAG-ESVNIRWSRNGLPIQADGHRVHQ-----SPDGT--- 1208

  Fly   299 VLRIDSVGEEDFGDYYCNATNKLGHADARLHLFQTVIPVPS 339
             |.|.::...|.|.|.|:|. :...|.:|....:..:|.|:
Mouse  1209 -LLIHNLRPRDEGSYTCSAF-RGSQAVSRSTEVKVALPAPA 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	24/158 (15%)
		Ig	37..127	CDD:299845	20/142 (14%)
		IG_like	154..234	CDD:214653	30/87 (34%)
		IGc2	161..223	CDD:197706	27/69 (39%)
		I-set	254..330	CDD:254352	24/77 (31%)
		IGc2	254..322	CDD:197706	22/69 (32%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229	19/84 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064		2/39 (5%)
		I-set	1070..1141	CDD:369462	30/85 (35%)
		Ig	1157..1241	CDD:386229	26/94 (28%)
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900