DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ama and Dscam

DIOPT Version :9

Sequence 1:	NP_731114.2	Gene:	Ama / 40831	FlyBaseID:	FBgn0000071	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	340	Identity:	86/340 - (25%)
Similarity:	139/340 - (40%)	Gaps:	75/340 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PVISQIS-KDVVASVGDSVEFNCTVEEVGQLSVSWAKRPSESDTNSVVLSMRNILSLPDQRYNVT 96
            |:.:.|| :.|.:|||..|..:|:|.......:||.:       |..:|:       |.:  ||.
Mouse   313 PLKATISPRKVKSSVGSQVSLSCSVTGNEDQELSWYR-------NGEILN-------PGK--NVR 361

  Fly    97 VTEGPKTGSAIYTFRIQNIEVSDMGPYECQVLVSATEKVTKKLSLQIKTPPVIAENTPK------ 155
            :| |....:.|....::    ||.|.|:|.|.       ..|||.|.....|:.:.|||
Mouse   362 IT-GLNHANLIMDHMVK----SDGGAYQCFVR-------KDKLSAQDYVQVVLEDGTPKIISAFS 414

  Fly   156 STLVTEGQNLELTCHANGFPKPTISWAREHNAVMPAGGHLLAE---------PTLRIRSVHRMDR 211
            ..:|:..:.:.|.|:..|.|.||::|..:.:.::...||.:::         ..|.|.|....|.
Mouse   415 EKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDG 479

  Fly   212 GGYYCIAQNGEGQPDKRLIRVEVEFRPQIAVQRP-------KIAQMVSHSAELECSVQGYPAPTV 269
            |.|.|.|.|..|         .|.::.:|.|:.|       .|..:......:.|.|.|||..::
Mouse   480 GVYRCTANNSAG---------VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSI 535

  Fly   270 VWHKNGVPLQSSRHHEVANTASSSGTTTSVLRIDSVGEE-DFGDYYCN-------ATNKLGHADA 326
            .|:|| ..|....|.:||  ..::||    |::..|.:| |.|:|.||       :|::..|...
Mouse   536 KWYKN-ANLLPFNHRQVA--FENNGT----LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTV 593

  Fly   327 RLHLFQTVIPVPSLS 341
            ::..|......|..|
Mouse   594 KVPPFIQPFEFPRFS 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ama	NP_731114.2	I-set	33..143	CDD:254352	29/110 (26%)
		Ig	37..127	CDD:299845	24/90 (27%)
		IG_like	154..234	CDD:214653	22/94 (23%)
		IGc2	161..223	CDD:197706	18/70 (26%)
		I-set	254..330	CDD:254352	24/83 (29%)
		IGc2	254..322	CDD:197706	23/75 (31%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652	27/107 (25%)
		Ig_3	410..488	CDD:372822	18/77 (23%)
		IGc2	518..575	CDD:197706	20/63 (32%)
		Ig	596..686	CDD:386229	3/13 (23%)
		Ig_DSCAM	707..784	CDD:143211
		Ig	802..889	CDD:386229
		FN3	885..978	CDD:238020
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900