DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bcd and HOXC8

DIOPT Version :9

Sequence 1:	NP_788587.1	Gene:	bcd / 40830	FlyBaseID:	FBgn0000166	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_073149.1	Gene:	HOXC8 / 3224	HGNCID:	5129	Length:	242	Species:	Homo sapiens

Alignment Length:	177	Identity:	43/177 - (24%)
Similarity:	70/177 - (39%)	Gaps:	45/177 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QNFYHH---PLPHTHTHPHPHS-------------HPHPHSHPHPHHQHPQLQLPPQFRNPFDLL 56
            |:|:||   .:.::....:|.|             ...|....:...|...:...|..::..:..
Human    57 QDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTN 121

  Fly    57 FDERTGAINYN--------YIRPYLPNQMPKPDVFPSEELPDSLVMRRPRRTRTTFTSSQIAELE 113
            ..|..|.:|.|        ::||:.|.:                     |..|.|::..|..|||
Human   122 SSEGQGHLNQNSSPSLMFPWMRPHAPGR---------------------RSGRQTYSRYQTLELE 165

  Fly   114 QHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHK 160
            :.||...|||..|..::|..|.|...||||||:|||.:.|.::::.|
Human   166 KEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDK 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeobox	106..153	CDD:278475	22/46 (48%)
HOXC8	NP_073149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..154		8/60 (13%)
		Antp-type hexapeptide	138..143		0/4 (0%)
		Homeobox	153..205	CDD:306543	24/51 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..242		1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900