DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bcd and HOXB8

DIOPT Version :9

Sequence 1:	NP_788587.1	Gene:	bcd / 40830	FlyBaseID:	FBgn0000166	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_076921.1	Gene:	HOXB8 / 3218	HGNCID:	5119	Length:	243	Species:	Homo sapiens

Alignment Length:	184	Identity:	55/184 - (29%)
Similarity:	75/184 - (40%)	Gaps:	52/184 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPPDQNFYHHPLPHTHTHPHPHSHPHP-----HSHPHPHHQHPQLQLPPQF--RNPFDL------ 55
            |...|.|||.| ....|.|:   ..:|     |..|...:.:..||....|  ::| ||
Human    51 PSQIQEFYHGP-SSLSTAPY---QQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDP-DLVQYADC 110

  Fly    56 -------LFDERTGAINYNYIRPYLPNQMPKP-DVFPSEELPDSLVMRRP------RRTRTTFTS 106
                   |.:|..|:           .|.|.| .:||         ..||      ||.|.|::.
Human   111 KLAAASGLGEEAEGS-----------EQSPSPTQLFP---------WMRPQAAAGRRRGRQTYSR 155

  Fly   107 SQIAELEQHFLQGRYLTAPRLADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHK 160
            .|..|||:.||...|||..|..::|..|.|...||||||:|||.:.|.::::.|
Human   156 YQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDK 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeobox	106..153	CDD:278475	22/46 (48%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		2/13 (15%)
		Homeobox	150..203	CDD:395001	24/52 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243		1/7 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900