DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bcd and hoxa2b

DIOPT Version :9

Sequence 1:	NP_788587.1	Gene:	bcd / 40830	FlyBaseID:	FBgn0000166	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_571181.1	Gene:	hoxa2b / 30325	ZFINID:	ZDB-GENE-990415-98	Length:	363	Species:	Danio rerio

Alignment Length:	307	Identity:	75/307 - (24%)
Similarity:	108/307 - (35%)	Gaps:	96/307 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNY 68
            |||    :...:|..:...||. |..|..:|:.....|...|||::.      :.:...|...|.
Zfish    49 PPP----FEQTIPSLNPGSHPR-HSRPKQNPNGSCPLPAASLPPEYP------WMKEKKASKKNQ 102

  Fly    69 IRPYLPNQMPKPDVFP---SEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPRLADL 130
            .........|.|..|.   |.|:.|. .....||.||.:|::|:.|||:.|...:||..||..::
Zfish   103 TTSTAATTDPGPLYFSPQGSPEISDG-GSGATRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEI 166

  Fly   131 SAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPN 195
            :|.|.|...|||:||:|||.:||.|: |.|:..:           .||.||||:
Zfish   167 AALLDLTERQVKVWFQNRRMKHKRQT-QCKENHH-----------GDGKPPSLE----------- 208

  Fly   196 ALTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGPGPGSTNVNGGQFF 260
                                                           ..||.|.|.:      ||
Zfish   209 -----------------------------------------------EAGGRGDGKS------FF 220

  Fly   261 QQQQVHNHQQQLHHQGNHVPHQMQQQQQQAQQQQY-HHFDFQQKQAS 306
            :|...:.....|..:|    :..||....:||.|. |:.|.|....|
Zfish   221 EQVANNVSGALLEREG----YPFQQNTLTSQQSQNGHNSDSQSATVS 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeobox	106..153	CDD:278475	20/46 (43%)
hoxa2b	NP_571181.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..132		21/94 (22%)
		Antp-type hexapeptide	88..93		0/10 (0%)
		Homeobox	137..189	CDD:278475	23/51 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..218		15/101 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..279		7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.900