DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bcd and GBX1

DIOPT Version :9

Sequence 1:	NP_788587.1	Gene:	bcd / 40830	FlyBaseID:	FBgn0000166	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001092304.1	Gene:	GBX1 / 2636	HGNCID:	4185	Length:	363	Species:	Homo sapiens

Alignment Length:	181	Identity:	47/181 - (25%)
Similarity:	65/181 - (35%)	Gaps:	60/181 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PKPDVFPS------EELPDSLVMRRP----RRTRTTFTSSQIAELEQHFLQGRYLTAPRLADLSA 132
            |||.:..|      |..|.:..:..|    ||.||.|||.|:.|||:.|...:||:....:.::.
Human   232 PKPKLKGSLGTGAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAH 296

  Fly   133 KLALGTAQVKIWFKNRRRRHK-IQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGGATPNA 196
            .|.|...||||||:|||.:.| |::.....:|              |:|.          ..|..
Human   297 ALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRS--------------GEPV----------RNPKI 337

  Fly   197 LTPSPTPSTPTAHMTEHYSESFNAYYNYNGGHNHAQANRHMHMQYPSGGGP 247
            :.|.|.                         |.:..|.|..|.|...|..|
Human   338 VVPIPV-------------------------HVNRFAVRSQHQQMEQGARP 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeobox	106..153	CDD:278475	19/46 (41%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..265		9/32 (28%)
		Homeobox	264..317	CDD:306543	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900