DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bcd and GSX1

DIOPT Version :9

Sequence 1:	NP_788587.1	Gene:	bcd / 40830	FlyBaseID:	FBgn0000166	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_663632.1	Gene:	GSX1 / 219409	HGNCID:	20374	Length:	264	Species:	Homo sapiens

Alignment Length:	198	Identity:	53/198 - (26%)
Similarity:	72/198 - (36%)	Gaps:	62/198 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PPPDQNFYHHPLPHTHTHPHPHSHPHPHSHPHPHHQHPQLQLPPQFRNPFDLLFDERTGAINYNY 68
            ||....:.|.||...|:...|.....|.:                          ....|..|..
Human    84 PPFGSQYCHAPLGRQHSAVSPGVAHGPAA--------------------------AAAAAALYQT 122

  Fly    69 IRPYLPNQMPKPDVF-------PSEELPDSLVMRRPRRTRTTFTSSQIAELEQHFLQGRYLTAPR 126
            ..|     :|.|..|       .|.:||.|      :|.||.|||:|:.|||:.|....||:..|
Human   123 SYP-----LPDPRQFHCISVDSSSNQLPSS------KRMRTAFTSTQLLELEREFASNMYLSRLR 176

  Fly   127 LADLSAKLALGTAQVKIWFKNRRRRHKIQSDQHKDQSYEGMPLSPGMKQSDGDPPSLQTLSLGGG 191
            ..:::..|.|...||||||:|||.:||   .:.|..::.|     |.....|          |||
Human   177 RIEIATYLNLSEKQVKIWFQNRRVKHK---KEGKGSNHRG-----GGGGGAG----------GGG 223

  Fly   192 ATP 194
            :.|
Human   224 SAP 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bcd	NP_788587.1	Homeobox	106..153	CDD:278475	20/46 (43%)
GSX1	NP_663632.1	SNAG domain. /evidence=ECO:0000250	1..20
		Homeobox	151..204	CDD:395001	26/55 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..264		10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900