Protein Alignment zen and NKX2-1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 67/284 - (23%)
• Similarity: 95/284 - (33%)
• Gaps: 93/284 - (32%)

  Fly    77 LPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNR 141
            |||.|.        ::.|..|:..|:.|||..||...||....|..:|..:.|...||||||||.
Human   186 LPSAPR--------RKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNH 242

  Fly   142 RMKFKKDIQGHREPKSNAKLAQPQAEQSA-------HRGIVKRLMSYSQDPRE---GTAAAEKRP 196
            |.|.|:        ::..|.||.|.:|.:       ..|..::..:..|.||.   .....:.:|
Human   243 RYKMKR--------QAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKP 299

  Fly   197 MMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSA 261
            ..|.||.......|...:.:.                  :|.||   |.|.:.|..|.| |..:.
Human   300 CQAGAPAPGAASLQGHAQQQA------------------QHQAQ---AAQAAAAAISVG-SGGAG 342

  Fly   262 SSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPILATQSWHPSSQSQVPTSVHAAPSMNLS 326
            ..:..||                                     .|.|..|.|...|.|.|
Human   343 LGAHPGH-------------------------------------QPGSAGQSPDLAHHAAS---- 366

  Fly   327 WGEPAA-KSRKLSVNHMNPCVTSY 349
               ||| :.:..|::|:|...:.|
Human   367 ---PAALQGQVSSLSHLNSSGSDY 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	23/55 (42%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	23/55 (42%)