Protein Alignment zen and NKX2-4

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 54/214 - (25%)
• Similarity: 83/214 - (38%)
• Gaps: 45/214 - (21%)

  Fly    13 AKVGSYSADPSEVKYSDL--IYGHHHDVNPIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDE 75
            |..|.|.|:| :.:||.:  ..|....||..|:        .:.|.:.|  :.:.:...|.::..
Human   132 AATGWYGANP-DPRYSSISRFMGPSAGVNVAGM--------GSLTGIAD--AAKSLGPLHAAAAA 185

  Fly    76 NLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQN 140
            ..|.           ::.|..|:..|:.|||..||...||....|..:|..:.|...||||||||
Human   186 AAPR-----------RKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQN 239

  Fly   141 RRMKFKKDIQGHREPKSNAKLAQ-------PQAEQSAHRGIVKRLMSYSQDPREGTA------AA 192
            .|.|.|:    ..:.|:..:|.|       |....|..|..|..|:...:..:.|.:      |.
Human   240 HRYKMKR----QAKDKAAQQLQQEGGLGPPPPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAG 300

  Fly   193 EKRPMMAVAP----VNPKP 207
            .:.|....||    ::|.|
Human   301 PQPPAPTPAPELEELSPSP 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	23/55 (42%)
NKX2-4	NP_149416.1	Homeodomain	190..246	CDD:459649	23/55 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		15/78 (19%)