Protein Alignment zen and NKX6-1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 165
• Identity: 46/165 - (27%)
• Similarity: 75/165 - (45%)
• Gaps: 34/165 - (20%)

  Fly    61 CSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQ 125
            |:|   ||..:..|:        |.:|   |.:|..|:..|:..||..|:...||....|..:|.
Human   221 CTP---HQGSILLDK--------DGKR---KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAY 271

  Fly   126 RLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTA 190
            .|.:.|.|||:||||||.|::|        |..|::|..:.:|.:.   .:||...|::..|...
Human   272 SLGMTESQVKVWFQNRRTKWRK--------KHAAEMATAKKKQDSE---TERLKGASENEEEDDD 325

  Fly   191 AAEKRPMMAVAPVNP-KPDYQASQKMKTEASTNNG 224
            ..:        |::| ..|.:.:|.:|...|::.|
Human   326 YNK--------PLDPNSDDEKITQLLKKHKSSSGG 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	23/55 (42%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133
		Repressor domain. /evidence=ECO:0000250	102..268		17/60 (28%)
		Homeodomain	235..293	CDD:459649	24/60 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		15/70 (21%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		12/58 (21%)