Protein Alignment zen and NKX2-2

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 60/271 - (22%)
• Similarity: 83/271 - (30%)
• Gaps: 94/271 - (34%)

  Fly    42 GLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELE 106
            |.||..:...|...:.::             |.:|....|.......|.::.|..|:..|..|||
Human    93 GAPPQDSSSKSPEPSADE-------------SPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELE 144

  Fly   107 NEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAH 171
            ..|:...||....|..:|..:.|...||||||||.|.|.|:
Human   145 RRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR------------------------ 185

  Fly   172 RGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILE 236
                              |.|||.  |.|.|: |.|     :::.......:|....|
Human   186 ------------------ARAEKG--MEVTPL-PSP-----RRVAVPVLVRDGKPCHA------- 217

  Fly   237 HLAQTTAAPQVSTATSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPILA 301
                 ..|..::.||...|...::.|:.|..|..||                 |...|.|.|...
Human   218 -----LKAQDLAAATFQAGIPFSAYSAQSLQHMQYN-----------------AQYSSASTPQYP 260

  Fly   302 TQSWHPSSQSQ 312
            |.  ||..|:|
Human   261 TA--HPLVQAQ 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	22/55 (40%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		8/50 (16%)
		Homeodomain	129..185	CDD:459649	22/55 (40%)