Protein Alignment zen and PDX1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 75/292 - (25%)
• Similarity: 111/292 - (38%)
• Gaps: 92/292 - (31%)

  Fly     1 MSSVMHYYPVHQ----------AKVGSYSADPSEVKY-----------------SDLIYGHHHDV 38
            |:....||...|          .....:||.|....|                 ..|..|...|:
Human     1 MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDI 65

  Fly    39 NPIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENLPSQPN------------HDSQRVKL- 90
            :|..:||           |.|..:..|:| .|:.:...||..|.            .:..||:|
Human    66 SPYEVPP-----------LADDPAVAHLH-HHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLP 118

  Fly    91 ----------------------------KRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRL 127
                                        ||:|||:|..||:|||.||..|.|:.|.||:|:|..|
Human   119 FPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVML 183

  Fly   128 SLCERQVKIWFQNRRMKFKKD---IQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGT 189
            :|.||.:||||||||||:||:   .:|.........:|:|:.:.:...|  :.|::....|..|.
Human   184 NLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSG--EELLALPPPPPPGG 246

  Fly   190 AAAEKRPMMA----VAP---VNPKPDYQASQK 214
            |.....|:.|    :.|   .:|:|...|.::
Human   247 AVPPAAPVAAREGRLPPGLSASPQPSSVAPRR 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	34/55 (62%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		10/70 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		5/36 (14%)
		Antp-type hexapeptide	118..123		0/4 (0%)
		Homeodomain	147..203	CDD:459649	34/55 (62%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		16/80 (20%)