DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen and HOXD3

DIOPT Version :9

Sequence 1:	NP_476793.1	Gene:	zen / 40828	FlyBaseID:	FBgn0004053	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	330	Identity:	103/330 - (31%)
Similarity:	134/330 - (40%)	Gaps:	79/330 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENL----------PSQPNHDSQRVKLKRSR 94
            |...|......:|:..|::....|.....:..|..:|.          .|.|...|:||     |
Human   139 PAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRV-----R 198

  Fly    95 TAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNA 159
            ||:||.||||||.||..|.||.|.||:|:|..|:|.|||:||||||||||:|||      .|:..
Human   199 TAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKD------QKAKG 257

  Fly   160 KLAQPQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNN- 223
            .|..| |.||..|           .|..|.||........:.|| |...|.|........|..|
Human   258 ILHSP-ASQSPER-----------SPPLGGAAGHVAYSGQLPPV-PGLAYDAPSPPAFAKSQPNM 309

  Fly   224 -GMCS-SADLSEILEHLAQTTAAPQVST-ATSSTGTSTNSASSSSS-----GHYSYNVDLVLQSI 280
             |:.: :|.||..|.. .:..|||:... ..:|.|....||:...|     |::
Human   310 YGLAAYTAPLSSCLPQ-QKRYAAPEFEPHPMASNGGGFASANLQGSPVYVGGNF----------- 362

  Fly   281 KQDLEAAAQAWSKSKSAPI--LATQSWHPSSQS-------QVPTSVHAAPSMNLSWGEPAAKSRK 336
               :|:.|.|     |.|:  |...| ||||.|       |:|.:.|..|.      :|......
Human   363 ---VESMAPA-----SGPVFNLGHLS-HPSSASVDYSCAAQIPGNHHHGPC------DPHPTYTD 412

  Fly   337 LSVNH 341
            ||.:|
Human   413 LSAHH 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeobox	93..146	CDD:278475	36/52 (69%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		10/57 (18%)
		Antp-type hexapeptide	160..165		1/4 (25%)
		Homeobox	198..250	CDD:306543	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		11/38 (29%)
		DUF4074	369..430	CDD:315871	18/61 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432		6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810