DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zen and HOXD1

DIOPT Version :9

Sequence 1:	NP_476793.1	Gene:	zen / 40828	FlyBaseID:	FBgn0004053	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_078777.1	Gene:	HOXD1 / 3231	HGNCID:	5132	Length:	328	Species:	Homo sapiens

Alignment Length:	185	Identity:	59/185 - (31%)
Similarity:	77/185 - (41%)	Gaps:	44/185 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VHQAKVGSYSADPSEVKYSDLIYGHHHDVNPI---------GLPPNYNQMNSNPTTLNDHCSPQH 65
            ||.|....:|...|.:....:.|....:..|.         |.|..:...:..|.|
Human   132 VHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKASADGHPGAFQTASPAPGT--------- 187

  Fly    66 VHQQHVSSDENLPSQPNHDSQRVKLKRS-------------------RTAFTSVQLVELENEFKS 111
             :.:.||....||:..: ..:.:|:||:                   ||.|::.||.|||.||..
Human   188 -YPKSVSPASGLPAAFS-TFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHF 250

  Fly   112 NMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQA 166
            |.||.|.||||||..|.|.:.||||||||||||.||     ||.:.....|.|.|
Human   251 NKYLTRARRIEIANCLHLNDTQVKIWFQNRRMKQKK-----REREGLLATAIPVA 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeobox	93..146	CDD:278475	34/71 (48%)
HOXD1	NP_078777.1	Antp-type hexapeptide	204..209		0/4 (0%)
		Homeobox	233..285	CDD:278475	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810