DRSC/TRiP Functional Genomics Resources

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Protein Alignment zen and TLX2

DIOPT Version :10

Sequence 1:NP_476793.1 Gene:zen / 40828 FlyBaseID:FBgn0004053 Length:353 Species:Drosophila melanogaster
Sequence 2:NP_057254.1 Gene:TLX2 / 3196 HGNCID:5057 Length:284 Species:Homo sapiens


Alignment Length:151 Identity:43/151 - (28%)
Similarity:70/151 - (46%) Gaps:26/151 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 KLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHR 153
            |.|:.||:|:..|::|||..|....||....|..:|:.|.:.:.|||.||||||.|:::      
Human   156 KRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRR------ 214

  Fly   154 EPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQAS----QK 214
                     |...|:.|.|....||:.:.|..      |..||:....|.:|...:.:|    |.
Human   215 ---------QTAEEREAERHRAGRLLLHLQQD------ALPRPLRPPLPPDPLCLHNSSLFALQN 264

  Fly   215 MKTEASTNNGMCSSADLSEIL 235
            ::..|. :|.:.|.:.|:.::
Human   265 LQPWAE-DNKVASVSGLASVV 284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zenNP_476793.1 Homeodomain 91..147 CDD:459649 24/55 (44%)
TLX2NP_057254.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..166 5/9 (56%)
Homeodomain 158..214 CDD:459649 24/55 (44%)
Blue background indicates that the domain is not in the aligned region.

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