Protein Alignment zen and Pdx1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_032840.1
• Gene: Pdx1 / 18609
• MGIID: 102851
• Length: 284
• Species: Mus musculus
• Alignment Length: 279
• Identity: 73/279 - (26%)
• Similarity: 103/279 - (36%)
• Gaps: 109/279 - (39%)

  Fly     1 MSSVMHYYPVHQ----------AKVGSYSADPSEVKY-----------------SDLIYGHHHDV 38
            |:|...||...|          ..|..:||:|....|                 ..|..|...|:
Mouse     1 MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFTSSLGSLEQGSPPDI 65

  Fly    39 NPIGLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDENLPSQ-----------PN-------HDS 85
            :|..:||          ..:|..:..|:|       .:||:|           ||       .:.
Mouse    66 SPYEVPP----------LASDDPAGAHLH-------HHLPAQLGLAHPPPGPFPNGTEPGGLEEP 113

  Fly    86 QRVKL-----------------------------KRSRTAFTSVQLVELENEFKSNMYLYRTRRI 121
            .||:|                             ||:|||:|..||:|||.||..|.|:.|.||:
Mouse   114 NRVQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRV 178

  Fly   122 EIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPR 186
            |:|..|:|.||.:||||||||||:||:     |.|..:     ....|...|        .::|.
Mouse   179 ELAVMLNLTERHIKIWFQNRRMKWKKE-----EDKKRS-----SGTPSGGGG--------GEEPE 225

  Fly   187 EGTAAAEKRPMMAVAPVNP 205
            :..|......::||.|:.|
Mouse   226 QDCAVTSGEELLAVPPLPP 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	34/55 (62%)
Pdx1	NP_032840.1	Transactivation domain. /evidence=ECO:0000250	13..73		11/69 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..116		17/102 (17%)
		Antp-type hexapeptide	119..124		0/4 (0%)
		Homeodomain	148..204	CDD:459649	34/55 (62%)
		Nuclear localization signal	198..204		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..284		12/61 (20%)