Protein Alignment zen and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 174
• Identity: 48/174 - (27%)
• Similarity: 78/174 - (44%)
• Gaps: 34/174 - (19%)

  Fly    61 CSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQ 125
            |:|   ||..:..|:        |.:|   |.:|..|:..|:..||..|:...||....|..:|.
Mouse   222 CTP---HQGSILLDK--------DGKR---KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAY 272

  Fly   126 RLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTA 190
            .|.:.|.|||:||||||.|::|        |..|::|..:.:|.:.   .:||        :||:
Mouse   273 SLGMTESQVKVWFQNRRTKWRK--------KHAAEMATAKKKQDSE---TERL--------KGTS 318

  Fly   191 AAEKRPMMAVAPVNP-KPDYQASQKMKTEASTNNGMCSSADLSE 233
            ..|:.......|::| ..|.:.:|.:|...|:...:...|..:|
Mouse   319 ENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASEAE 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	23/55 (42%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136
		Repressor domain. /evidence=ECO:0000250	102..269		17/60 (28%)
		Homeodomain	236..294	CDD:459649	24/60 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		17/79 (22%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		14/67 (21%)