Protein Alignment zen and Nkx2-3

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_032725.1
• Gene: Nkx2-3 / 18089
• MGIID: 97348
• Length: 362
• Species: Mus musculus
• Alignment Length: 290
• Identity: 71/290 - (24%)
• Similarity: 95/290 - (32%)
• Gaps: 60/290 - (20%)

  Fly    55 TTLNDHCSPQHVHQQHVSSDENLPS-------------QPNHDSQRVK---LKRSRTAFTSVQLV 103
            |.|.|.||.....::.|.|:.:..|             :.:.|.:|.|   .::.|..|:..|:.
Mouse    94 TVLRDACSGPKEQEEEVVSERSQKSCQLKKSLEAAGDCKTSEDGERPKPRSRRKPRVLFSQAQVF 158

  Fly   104 ELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQG-------HREPKSNAKL 161
            |||..||...||....|..:|..|.|...||||||||||.|.|:..|.       |..|....::
Mouse   159 ELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGTHAPPPPPRRV 223

  Fly   162 A--------QPQAEQSAHR-----GIVKRLMSYSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQ 213
            |        :|....||..     |:.....||:..|..|...:......|.|.......|..|.
Mouse   224 AVPVLVRDGKPCVTPSAQTYGSPYGVGAGAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSGSY 288

  Fly   214 KMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTAT---SSTGTSTNSASSSSSGHYSYNVDL 275
            ..........|...:|.        |.|||.....:||   |....|......|..|
Mouse   289 GCAYPTGGGGGGGGTAS--------AATTAMQPACSATGGGSFVNVSNLGGFGSGGG-------- 337

  Fly   276 VLQSIKQDLEAAAQAWSKSKSAPILATQSW 305
                 .|.|...|.|.|......:...::|
Mouse   338 -----AQPLHQGAAAGSACTQGTLQGIRAW 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	25/55 (45%)
Nkx2-3	NP_032725.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..149		3/22 (14%)
		Homeodomain	146..202	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..222		3/18 (17%)