DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen and Hoxa3

DIOPT Version :9

Sequence 1:	NP_476793.1	Gene:	zen / 40828	FlyBaseID:	FBgn0004053	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_034582.1	Gene:	Hoxa3 / 15400	MGIID:	96175	Length:	443	Species:	Mus musculus

Alignment Length:	355	Identity:	94/355 - (26%)
Similarity:	125/355 - (35%)	Gaps:	140/355 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PPNYNQMNSNPTTLNDHCSP-------------------QHVHQ--------QHVSSDENLPSQP 81
            ||  ...|||||..:...||                   |:..|        :..:.|::.|.|.
Mouse   128 PP--QSANSNPTPASTAKSPLLNSPTVGKQIFPWMKESRQNTKQKTSGSSSGESCAGDKSPPGQA 190

  Fly    82 NHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFK 146
            :.       ||:|||:||.||||||.||..|.||.|.||:|:|..|:|.|||:||||||||||:|
Mouse   191 SS-------KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYK 248

  Fly   147 KDIQG----------------------------HR-------EPKSNAKLAQPQAEQSAHRGIVK 176
            ||.:|                            |.       ||:|....::|  .|.|
Mouse   249 KDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKP--PQGA------ 305

  Fly   177 RLMSYSQDPREGTAAAEKRPMMAVAPVNP--------------KPDY-------QASQKMKT--- 217
                |...|     |:...|:.:.||..|              .|||       |.:....|
Mouse   306 ----YGLPP-----ASYPAPLPSCAPPPPPQKRYTAAGSGAGGTPDYDPHAHGLQGNGSYGTPHL 361

  Fly   218 ------------EASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSSGHYS 270
                        |..:|:|....      |.||..||:|......|...|:..:........|.:
Mouse   362 QGSPVFVGGSYVEPMSNSGPLFG------LTHLPHTTSAAMDYGGTGPLGSGHHHGPGPGEPHPT 420

  Fly   271 YNVDLVLQSIKQDLEAAAQAWSKSKSAPIL 300
            |.          ||.|...:..:.:.||.|
Mouse   421 YT----------DLTAHHPSQGRIQEAPKL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeobox	93..146	CDD:278475	36/52 (69%)
Hoxa3	NP_034582.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..151		9/24 (38%)
		Antp-type hexapeptide	156..161		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..197		7/40 (18%)
		COG5576	<182..309	CDD:227863	53/145 (37%)
		Homeobox	196..249	CDD:365835	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..354		22/122 (18%)
		DUF4074	378..441	CDD:372548	18/79 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..443		10/50 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770