Protein Alignment zen and Hhex

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 214
• Identity: 66/214 - (30%)
• Similarity: 94/214 - (43%)
• Gaps: 34/214 - (15%)

  Fly     9 PVHQAKVGSYSADPSEVKYSDLIYGHHHDVNPIGL-PPNYNQMNSNPTTLNDHCSPQHVHQQHVS 72
            |||.|    :|..|:....:  .||      |.|. .|.|    ..|.|:||:   .|...:|..
Mouse    75 PVHPA----FSHHPAAALAA--AYG------PSGFGGPLY----PFPRTVNDY---THALLRHDP 120

  Fly    73 SDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIW 137
            ..:.|...|.......|.|..:..|::.|.||||.:|::..||....|..:|:.|.|.|||||.|
Mouse   121 LGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTW 185

  Fly   138 FQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQD-PRE-GTAAAEKRPMMAV 200
            |||||.|:::..|  ..|:||.|.|....:.|..:|         || |.| ...|:..|...:.
Mouse   186 FQNRRAKWRRLKQ--ENPQSNKKDALDSLDTSCEQG---------QDLPSEQNKGASLDRSQCSP 239

  Fly   201 APVNPK-PDYQASQKMKTE 218
            :|.:.: ||.:.|:....|
Mouse   240 SPASQEDPDSEISEDSDQE 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	26/55 (47%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		20/81 (25%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		45/132 (34%)
		Homeodomain	143..195	CDD:459649	25/51 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		19/75 (25%)