Protein Alignment zen and NKX2-6

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 219
• Identity: 54/219 - (24%)
• Similarity: 79/219 - (36%)
• Gaps: 50/219 - (22%)

  Fly    80 QPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMK 144
            ||....:|    :.|..|:..|::.||..||...||....|..:|..|.|...||||||||||.|
Human   126 QPKARQRR----KPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYK 186

  Fly   145 FKK-------DIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREGTAAAEKRPMMAVAP 202
            .|:       ::.||  |.:..::|.|         ::.|.......|..|..|.......||:|
Human   187 CKRQRQDKSLELAGH--PLTPRRVAVP---------VLVRDGKPCLGPGPGAPAFPSPYSAAVSP 240

  Fly   203 VNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSSG 267
            .:....|..:     ......|.|           .|...:.|...|..:|.|......:::..|
Human   241 YSCYGGYSGA-----PYGAGYGTC-----------YAGAPSGPAPHTPLASAGFGHGGQNATPQG 289

  Fly   268 HYSYNVDLVLQSIKQDLEAAAQAW 291
            |.:    ..||.::        ||
Human   290 HLA----ATLQGVR--------AW 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	24/55 (44%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		3/12 (25%)
		Homeodomain	133..189	CDD:459649	25/59 (42%)