Protein Alignment zen and Cdx2

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_031699.2
• Gene: Cdx2 / 12591
• MGIID: 88361
• Length: 311
• Species: Mus musculus
• Alignment Length: 222
• Identity: 64/222 - (28%)
• Similarity: 93/222 - (41%)
• Gaps: 45/222 - (20%)

  Fly    11 HQAKVGSYSA-----DPSEVKYSDLIYGHHHDVNPIGLPP----NYNQMNSNP-----TTLNDHC 61
            |....||.:|     .|:|  |....:.|||..:|...|.    ....:|..|     |...:..
Mouse    93 HGLNGGSPAAAMGYSSPAE--YHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQL 155

  Fly    62 SPQHVHQQHVSSDENLPSQPNHDSQRVKLK---RSRTAFTSVQLVELENEFKSNMYLYRTRRIEI 123
            ||.. .::::......|:|.:..|| ||.:   :.|..:|..|.:|||.||..:.|:...|:.|:
Mouse   156 SPSG-QRRNLCEWMRKPAQQSLGSQ-VKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSEL 218

  Fly   124 AQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMSYSQDPREG 188
            |..|.|.||||||||||||.|         |.|...|..|.|.:|.            .|.|:..
Mouse   219 AATLGLSERQVKIWFQNRRAK---------ERKIKKKQQQQQQQQQ------------QQPPQPP 262

  Fly   189 TAAAEKRP--MMAV-APVNPKPDYQAS 212
            ...::.:|  :.:| .|::|....|.|
Mouse   263 PQPSQPQPGALRSVPEPLSPVTSLQGS 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	27/58 (47%)
Cdx2	NP_031699.2	Caudal_act	13..178	CDD:461413	19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..151		10/41 (24%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626	185..215		9/29 (31%)
		Homeodomain	187..242	CDD:459649	28/63 (44%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626	227..241		12/22 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..311		15/72 (21%)
		4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724	281..293		3/9 (33%)