Protein Alignment zen and VAX1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001106175.1
• Gene: VAX1 / 11023
• HGNCID: 12660
• Length: 334
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 81/308 - (26%)
• Similarity: 120/308 - (38%)
• Gaps: 78/308 - (25%)

  Fly    42 GLPPNYNQMNSNPTTLNDHCSPQHVHQQHVSSDE-NLPSQPNHDSQRVKLKRSRTAFTSVQLVEL 105
            |...:.|:..||.....|:|....|.....|..| .||...:.|    :.||:||:||:.||..|
Human    55 GAAEDCNKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLD----RPKRTRTSFTAEQLYRL 115

  Fly   106 ENEFKSNMYLYRTRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSA 170
            |.||:...|:....|.|:|::|:|.|.|||:||||||.|.||| ||     .:::|....:|.:|
Human   116 EMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKD-QG-----KDSELRSVVSETAA 174

  Fly   171 HRGIVK-----RLMSYSQDPR-----------------------EGTAAAEKRPMMAVAPVNPKP 207
            ...:::     ||:|....|.                       .|.||.......|.||
Human   175 TCSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAP----- 234

  Fly   208 DYQASQKMKTEASTNNGMCSSADLSEILEHLAQTTAAPQVSTATSSTGTSTNSASSSSSGH--YS 270
                            |...:|.     .|......||....|    |.....|.:.::||  :|
Human   235 ----------------GPAGAAS-----PHPPAVGGAPGPGPA----GPGGLHAGAPAAGHSLFS 274

  Fly   271 YNVDLVLQSIKQDLEAAAQAWSKS-------KSAPILATQSWHPSSQS 311
            ..|..:|.|:...|.:|....:.|       .||..|::.::.|.|::
Human   275 LPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSARYLSSSAFEPYSRT 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	29/55 (53%)
VAX1	NP_001106175.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41
		COG5576	66..184	CDD:227863	46/127 (36%)
		Homeodomain	101..157	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..263		8/58 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..334		2/9 (22%)