Protein Alignment zen and CDX1

DIOPT Version :10

• Sequence 1: NP_476793.1
• Gene: zen / 40828
• FlyBaseID: FBgn0004053
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 184
• Identity: 52/184 - (28%)
• Similarity: 68/184 - (36%)
• Gaps: 58/184 - (31%)

  Fly    17 SYSADPSEVKYS--DLIYGHHHDVNPIGLPPN-----YNQMNSNPTTLNDHCSPQHVHQQHVSSD 74
            :|...|:....|  .|.:|...|.:|:..||.     ..|....|.|
Human    75 AYGPGPAAPAASPASLAFGPPPDFSPVPAPPGPGPGLLAQPLGGPGT------------------ 121

  Fly    75 ENLPSQPNHDSQRVK----LKRS------------------RTAFTSVQLVELENEFKSNMYLYR 117
               ||.|.  :||..    ::||                  |..:|..|.:|||.||..:.|:..
Human   122 ---PSSPG--AQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITI 181

  Fly   118 TRRIEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAH 171
            .|:.|:|..|.|.||||||||||||.|.:|      ..|...:..||.....||
Human   182 RRKSELAANLGLTERQVKIWFQNRRAKERK------VNKKKQQQQQPPQPPMAH 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zen	NP_476793.1	Homeodomain	91..147	CDD:459649	29/73 (40%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		19/100 (19%)
		Caudal_act	13..142	CDD:461413	19/89 (21%)
		Homeodomain	156..211	CDD:459649	27/54 (50%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		8/20 (40%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		10/10 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		7/29 (24%)