DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen2 and HOXD3

DIOPT Version :9

Sequence 1:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	236	Identity:	77/236 - (32%)
Similarity:	99/236 - (41%)	Gaps:	75/236 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRKGA 107
            |||.|||::|.||:|||:|||.|:||.|.||:|::..|.|||||:||||||||||.||....||.
Human   194 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGI 258

  Fly   108 IGALTTSIPLSSQSSEDLQKDDQIVERLLRYANTNVETAPLRQVDHGVLEEGQITP-PYQSYD-- 169
            :.:     | :|||.|                    .:.||......|...||:.| |..:||
Human   259 LHS-----P-ASQSPE--------------------RSPPLGGAAGHVAYSGQLPPVPGLAYDAP 297

  Fly   170 --------------------------------YLHEFSPEPMALPQLPFNEFDANWASSWLGLEP 202
                                            ...||.|.|||       .....:||:.|...|
Human   298 SPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMA-------SNGGGFASANLQGSP 355

  Fly   203 TIPIAENVIEHNTQDQPMIQNFCWDSNSSSASSSDILDVDY 243
             :.:..|.:|........:.|....|:.||||      |||
Human   356 -VYVGGNFVESMAPASGPVFNLGHLSHPSSAS------VDY 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	35/52 (67%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		2/2 (100%)
		Antp-type hexapeptide	160..165
		Homeobox	198..250	CDD:306543	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		9/52 (17%)
		DUF4074	369..430	CDD:315871	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810