DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen2 and hoxb2a

DIOPT Version :9

Sequence 1:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_571191.1	Gene:	hoxb2a / 30338	ZFINID:	ZDB-GENE-990415-103	Length:	390	Species:	Danio rerio

Alignment Length:	258	Identity:	82/258 - (31%)
Similarity:	110/258 - (42%)	Gaps:	85/258 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKST--NRK 105
            |:|.|||:::.||:|||:|||.||||.|.||:||:..|.|||||||:||||||||.|:.|  :|.
Zfish   158 SRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTTHHRD 222

  Fly   106 GAIG---------ALTTSIPLSSQSSE------DLQKDDQIVERLLRYANTNVETAPLRQVDHGV 155
            |..|         ....|.|.||||.|      ....:.:.......|.|::.::.|       .
Zfish   223 GQEGEPSGFDLLEGTDASSPYSSQSLEVSGSGSAAPSESETCPTTAAYTNSSDKSQP-------T 280

  Fly   156 LEEGQITPPYQSYDYLHEFSPEPMALPQL-----PFNEFDANWASSWLGLEPTIPIAENVI---- 211
            .||||.:            .|||.::|..     |:               || |.|:|..
Zfish   281 PEEGQAS------------QPEPASVPDTAVHSPPY---------------PT-PTADNPTTMAE 317

  Fly   212 ------EHN-TQDQ-----PMIQNFCWDS------------NSSSASSSDILDVDYDFIQNLL 250
                  ||: |:.|     |.:..|..||            .||..|..|..:.|:|...:.|
Zfish   318 GRAAGPEHSFTEPQDATSLPDLNFFSTDSCLQISDALSPSLQSSLDSPVDFSEEDFDLFTSTL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	36/52 (69%)
hoxb2a	NP_571191.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Antp-type hexapeptide	103..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..155
		Homeobox	162..214	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..338		35/161 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810