DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen2 and Pdx1

DIOPT Version :9

Sequence 1:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_074043.4	Gene:	Pdx1 / 29535	RGDID:	62387	Length:	283	Species:	Rattus norvegicus

Alignment Length:	154	Identity:	59/154 - (38%)
Similarity:	85/154 - (55%)	Gaps:	24/154 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EKSKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRK 105
            |::||:|||::..||:|||:||..|||::|.||:|::..|.||||.:||||||||||.||..::|
  Rat   144 EENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKK 208

  Fly   106 GAIGALTTSIPLSSQSSEDLQKDDQIV--ERLLRYANTNVETAPLRQVDHGV---LEEGQITPPY 165
            .:.|  |||   .....|:.::|..:.  |.||...   ....|...|..||   ..||::....
  Rat   209 RSSG--TTS---GGGGGEEPEQDCAVTSGEELLALP---PPPPPGGAVPSGVPAAAREGRLPSGL 265

  Fly   166 QSYDYLHEFSPEPMAL----PQLP 185
            .:       ||:|.::    ||.|
  Rat   266 SA-------SPQPSSIAPLRPQEP 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	32/52 (62%)
Pdx1	NP_074043.4	Transactivation domain	13..73
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..81
		Antp-type hexapeptide	118..123
		Homeobox	149..203	CDD:395001	32/53 (60%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..283		24/97 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810