DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen2 and Hoxd3

DIOPT Version :9

Sequence 1:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_034598.2	Gene:	Hoxd3 / 15434	MGIID:	96207	Length:	433	Species:	Mus musculus

Alignment Length:	234	Identity:	78/234 - (33%)
Similarity:	103/234 - (44%)	Gaps:	71/234 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKSTNRKGA 107
            |||.|||::|.||:|||:|||.|:||.|.||:|::..|.|||||:||||||||||.||....||.
Mouse   195 SKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGI 259

  Fly   108 IGALTTSIPLSSQSSEDLQKDDQIVERLLRYANTNVETAPLRQVDHGVLEEGQITP-PYQSYDYL 171
            :.:     | :.||.|                    .:.||......|...||:.| |..:||
Mouse   260 LHS-----P-AGQSPE--------------------RSPPLGGAAGHVAYSGQLPPVPGLAYD-- 296

  Fly   172 HEFSPEPMA---------------------LPQ---LPFNEFD--------ANWASSWLGLEPTI 204
               :|.|.|                     |||   .|..||:        ..:||:.|...| :
Mouse   297 ---APSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYPAPEFEPHPMASNGGGFASANLQGSP-V 357

  Fly   205 PIAENVIEHNTQDQPMIQNFCWDSNSSSASSSDILDVDY 243
            .:..|.::........:.|....|:.||||      |||
Mouse   358 YVGGNFVDSMAPTSGPVFNLGHLSHPSSAS------VDY 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	35/52 (67%)
Hoxd3	NP_034598.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..198		2/2 (100%)
		Antp-type hexapeptide	161..166
		Homeobox	199..251	CDD:278475	35/51 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..280		7/47 (15%)
		DUF4074	370..431	CDD:290032	9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770