DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zen2 and Hoxa2

DIOPT Version :9

Sequence 1:	NP_476794.1	Gene:	zen2 / 40827	FlyBaseID:	FBgn0004054	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_036713.2	Gene:	Hoxa2 / 103690123	RGDID:	2813	Length:	372	Species:	Rattus norvegicus

Alignment Length:	253	Identity:	74/253 - (29%)
Similarity:	116/253 - (45%)	Gaps:	71/253 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SKRSRTAFSSLQLIELEREFHLNKYLARTRRIEISQRLALTERQVKIWFQNRRMKLKKST----- 102
            |:|.|||:::.||:|||:|||.||||.|.||:||:..|.|||||||:||||||||.|:.|
  Rat   139 SRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKEN 203

  Fly   103 -NRKGAIGALTTSIPLSSQSSEDLQKDDQ---IVERLLRYANTNVE---------TAPLRQVDHG 154
             |.:|....|        :.|:.:::|::   :.|:.|..:...:|         ....:|..:|
  Rat   204 QNSEGKFKNL--------EDSDKVEEDEEEKSLFEQALSVSGALLEREGYTFQQNALSQQQAPNG 260

  Fly   155 VLEEGQITP--PYQSYDY--------------------------LHEFSPEPMALPQL-PFNEFD 190
            ...:.|..|  |..|.:.                          |:..|||.:.:|.| .||.|.
  Rat   261 HNGDSQTFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVPSLQDFNVFS 325

  Fly   191 ANWASSWL----GLEPTIPIAENVIEHNTQDQPM-IQNFCWDSNSSSASSSDILDVDY 243
            .:   |.|    .|.|::|        .:.|.|: |....:|..:.:.::.|:..::|
  Rat   326 TD---SCLQLSDALSPSLP--------GSLDSPVDISADSFDFFTDTLTTIDLQHLNY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zen2	NP_476794.1	Homeobox	46..99	CDD:278475	36/52 (69%)
Hoxa2	NP_036713.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..96
		Antp-type hexapeptide	96..101
		Homeobox	143..196	CDD:395001	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..225		7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910